PUBLICATIONS

Results 2018-2019

 

BIONANODEN

  1. Cena-Diez, R.; Martin-Moreno, A.; de la Mata, F. J.; Gomez-Ramirez, R.; Munoz, E.; Ardoys, M.; Munoz-Fernandez, M. A.  G1-S4 or G2-S16 carbosilane dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity. Int. J. Nanomedicine 2019, 14,2371-2380.

  2. del Olmo, N. S.; Carloni, R.; Bajo, A. M.; Ortega, P.; Fattori, A.; Gomez, R.; Ottaviani, M. F.; Garcia-Gallego, S.; Cangiotti, M.; de la Mata, F. J.  Insight into the antitumor activity of carbosilane Cu(ii)-metallodendrimers through their interaction with biological membrane models. Nanoscale 2019, 11, (28),13330-13342.

  3. Fernandez, J.; Acosta, G.; Pulido, D.; Maly, M.; Copa-Patino, J. L.; Soliveri, J.; Royo, M.; Gomez, R.; Albericio, F.; Ortega, P.; de la Mata, F. J.  Carbosilane Dendron-Peptide Nanoconjugates as Antimicrobial Agents. Mol. Pharm. 2019, 16, (6),2661-2674.

  4.  Holota, M.; Magiera, J.; Michlewska, S.; Kubczak, M.; del Olmo, N. S.; Garcia-Gallego, S.; Ortega, P.; de la Mata, F. J.; Ionov, M.; Bryszewska, M.  In Vitro Anticancer Properties of Copper Metallodendrimers. Biomolecules 2019, 9, (4).

  5. Krasheninina, O. A.; Apartsin, E. K.; Fuentes, E.; Szulc, A.; Ionov, M.; Venyaminova, A. G.; Shcharbin, D.; de la Mata, F. J.; Bryszewska, M.; Gomez, R.  Complexes of Pro-Apoptotic siRNAs and Carbosilane Dendrimers: Formation and Effect on Cancer Cells. Pharmaceutics 2019, 11, (1).

  6. Maroto-Diaz, M.; del Olmo, N. S.; Munoz-Moreno, L.; Bajo, A. M.; Carmena, M. J.; Gomez, R.; Garcia-Gallego, S.; de la Mata, F. J.  In vitro and in vivo evaluation of first-generation carbosilane arene Ru(II)- metallodendrimers in advanced prostate cancer. European Polymer Journal 2019, 113,229-235.

  7. Martin-Perez, T.; Lozano-Cruz, T.; Criado-Fornelio, A.; Ortega, P.; Gomez, R.; de la Mata, F. J.; Perez-Serrano, J.  Synthesis and in vitro activity of new biguanide-containing dendrimers on pathogenic isolates of Acanthamoeba polyphaga and Acanthamoeba griffini. Parasitology Research 2019, 118, (6),1953-1961.

  8. Sanchez-Milla, M.; Munoz-Moreno, L.; Sanchez-Nieves, J.; Maly, M.; Gomez, R.; Carmena, M. J.; de la Mata, F. J.  Anticancer Activity of Dendriplexes against Advanced Prostate Cancer from Protumoral Peptides and Cationic Carbosilane Dendrimers. Biomacromolecules 2019, 20, (3),1224-1234.

  9. Vasquez-Villanueva, R.; Pena-Gonzalez, C. E.; Sanchez-Nieves, J.; de la Mata, F. J.; Marina, M. L.; Garcia, M. C.  Gold nanoparticles coated with carbosilane dendrons in protein sample preparation. Microchimica Acta 2019, 186, (8).

  10. Shcharbin, D  ; Pedziwiatr-Werbicka, E; Serchenya, T; Cyboran-Mikolajczyk, S; Prakhira, L; Abashkin, V; Dzmitruk, V; Lonov, M; Loznikova, S; Shyrochyna, L;  Sviridov, O; Pena-Gonzalez, CE ; Gumiel, AB ; Gomez, R; de la Mata, FJ; Bryszewska, M. Role of cationic carbosilane dendrons and metallic core of functionalized gold nanoparticles in their interaction with human serum albumin. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 118, 1773-1780  Subdivisión: B. DOI: 10.1016/j.ijbiomac.2018.07.023

  11. Lozano-Cruz, T ; Gomez, R; de la Mata, FJ ; Ortega, P. New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent. NEW JOURNAL OF CHEMISTRY 2018, 42 (14), 11732-11738. DOI: 10.1039/c8nj01713a

  12. Sepulveda-Crespo, D; de la Mata, FJ  ; Gómez, R  ; Muñoz-Fernandez, MA. Sutfonate-ended carbosilane dendrimers with a flexible scaffold cause inactivation of HIV-1 virions and gp120 shedding. NANOSCALE 2018, 10 (19), 8998-9011. DOI: 10.1039/c8nr01664j

  13. Guerrero-Beltran, C; Rodriguez-Izquierdo, I; Serramia, MJ; Araya-Duran, I; Marquez-Miranda, V  ; Gomez, R; de la Mata, FJ; Leal, M; Gonzalez-Nilo, F ; Muñoz-Fernandez, MA. Anionic Carbosilane Dendrimers Destabilize the GP120-CD4 Complex Blocking HIV-1 Entry and Cell to Cell Fusion. BIOCONJUGATE CHEMISTRY 2018, 29 (5), 1584-1594.DOI: 10.1021/acs.bioconjchem.8b00106.

  14. Michlewska, S; Ionov, M ; Maroto-Diaz, M; Szwed, A; Ihnatsyeu-Kachan, A; Loznikova, S; Shcharbin, D; Maly, M; Ramirez, RG; de la Mata, FJ; Bryszewska, M. Ruthenium dendrimers as carriers for anticancer siRNA. JOURNAL OF INORGANIC BIOCHEMISTRY, 2018, 181,18-27. DOI: 10.1016/j.jinorgbio.2018.01.001

  15. Heredero-Bermejo, I ; Hernandez-Ros, JM ; Sanchez-Garcia, L ; Maly, M ; Verdu-Exposito, C ; Soliveri, J ; de la Mata, FJ ; Copa-Patino, JL ; Perez-Serrano, J ; Sanchez-Nieves, J  , Gomez, R.  Ammonium and guanidine carbosilane dendrimers and dendrons as microbicides. EUROPEAN POLYMER JOURNAL, 2018,  101,  159-168. DOI: 10.1016/j.eurpolymj.2018.02.025

  16. Pedziwiatr-Werbicka, E; Serchenya, T; Shcharbin, D; Terekhova, M; Prokhira, E ; Dzmitruk, V; Shyrochyna, I; Sviridov, O; Pena-Gonzalez, CE; Gomez, R; Sanchez-Nieves, J ; de la Mata, FJ ; Bryszewska, M. Dendronization of gold nanoparticles decreases their effect on human alpha-1-microglobulin. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2018, 108, 936-941. DOI: 10.1016/j.ijbiomac.2017.11.004

  17. Sanchez-Milla, M  ; Pastor, I ; Maly, M ; Serramia, MJ ; Gomez, R  ; Sanchez-Nieves, J ; Ritort, F ; Muñoz-Fernandez, MA ; de la Mata, FJ. Study of non-covalent interactions on dendriplex formation: Influence of hydrophobic, electrostatic and hydrogen bonds interactions. COLLOIDS AND SURFACES B-BIOINTERFACES 2018, 162, 380-388. DOI: 10.1016/j.colsurfb.2017.12.009

  18. Gutierrez-Ulloa, CE ; Buyanova, MY ; Apartsin, EK ; Venyaminova, AGde la Mata, FJ ; Gomez, R. Carbon Nanotubes Decorated with Cationic Carbosilane Dendrons and Their Hybrids with Nucleic Acids. CHEMNANOMAT 2018,4 (2), 220-230. DOI: 10.1002/cnma.201700351

 

 

Grupo Laboratorio de Glicosistemas:

  1. Palomares, F.; Ramos-Soriano, J.; Gomez, F.; Mascaraque, A.; Bogas, G.; Richard Perkins, J.; Gonzalez, M.; Jose Torres, M.; Diaz-Perales, A.; Rojo, J.; Mayorga, C.  Pru p 3-Glycodendropeptides Based on Mannoses Promote Changes in the Immunological Properties of Dendritic and T-Cells from LTP-Allergic Patients. Molecular Nutrition & Food Research 2019, 63, (20).

  2. Ramos-Soriano, J.; Reina, J. J.; Illescas, B. M.; de la Cruz, N.; Rodriguez-Perez, L.; Lasala, F.; Rojo, J.; Delgado, R.; Martin, N.  Synthesis of Highly Efficient Multivalent Disaccharide/ 60 Fullerene Nanoballs for Emergent Viruses. Journal of the American Chemical Society 2019, 141, (38), 15403-15412.

  3. Rodriguez, M. J.; Ramos-Soriano, J.; Perkins, J. R.; Mascaraque, A.; Torres, M. J.; Gomez, F.; Diaz-Perales, A.; Rojo, J.; Mayorga, C.  Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model. Scientific Reports 2019, 9.

  4. Benede, S.; Ramos-Soriano, J.; Palomares, F.; Losada, J.; Mascaraque, A.; Carlos Lopez-Rodriguez, J.; Rojo, J.; Mayorga, C.; Villalba, M.; Batanero, E.  Peptide Glycodendrirners as Potential Vaccines for Olive Pollen Allergy. Molecular Pharmaceutics 2019, 17, (3), 827-836.

  5. Javier Ramos-Soriano, Jose Juan Reina, Beatriz M Illescas, Javier Rojo, and Nazario Martín. Maleimide and Cyclooctyne Based Hexakis-Adducts of Fullerene: Multivalent Scaffolds for Copper-Free Click Chemistry on Fullerenes. J. Org. Chem., 2018, 83, 1727−1736. DOI: 10.1021/acs.joc.7b02402

  6. Cíntia de Almeida Gonçalves, Rute Cunha Figueiredo, Alessandra Giani, Daniel Collado, Ezequiel Pérez-Inestrosa, Javier Rojo, Cleber Cunha Figueredo. Detection of glycidic receptors in microalgae using glycodendrons as probes: a new tool for studies on cell surface interactions. J. Appl. Phycol. 2018, DOI: 10.1007/s10811-018-1555-6

  7. Laura Rodríguez-Pérez, Javier Ramos-Soriano, Alfonso Pérez-Sánchez, Beatriz M. Illescas, Antonio Muñoz, Joanna Luczkowiak, Fátima Lasala, Javier Rojo, Rafael Delgado, and Nazario Martín. Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection. J. Am. Chem. Soc., 2018, 140, 9891-9898, DOI: 10.1021/jacs.8b03847

  8. Maria Jose Rodriguez, Francisca Palomares, Gador Bogas, Maria Jose Torres, Araceli Diaz-Perales, Javier Rojo, Maria del Carmen Plaza-Seron, Alba Rodriguez-Nogales, Christine Orengo, Cristobalina Mayorga,* and James Richard Perkins.Transcriptional Profiling of Dendritic Cells in a Mouse Model of Food-Antigen-Induced Anaphylaxis Reveals the Upregulation of Multiple Immune-Related PathwaysREF. REVISTA/LIBRO: Mol. Nut. Food Res. 2019, 63, DOI: 10.1002/mnfr.201800759

Laboratorio de Dendrímeros Biomiméticos y Fotónica (LDBF)

 

  1. Noemi Molina, Francisco Nájera, Juan A. Guadix, Jose M. Perez-Pomares, Yolanda Vida and Ezequiel Perez-Inestrosa. Synthesis of Amino Terminal Clicked dendrimers. Approaches to the application as a biomarker Journal of Organic Chemistry, 2019, 84 (16), 10197-10208. DOI: 10.1021/acs.joc.9b01369

  2. Noemi Molina; Marvin Cnudde; Juan A. Guadix; Jose M. Perez-Pomares; Cristian Strassert; Yolanda Vida; Ezequiel Perez-Inestrosa. A platinum-doped dendritic structure as a phosphorescent label for bacteria in two-photon excitation microscopy.  ACS Omega, 2019, 4 (8), 13027-13033.

  3. DOI: 10.1021/acsomega.9b0063

  4. Carlos Benitez-Martin, Juan A. Guadix, John R. Pearson, Francisco Najera, Jose M. Perez-Pomares, Ezequiel Perez-Inestrosa.  A Turn-On Two-Photon Fluorescent Probe for Detecting Lysosomal Hydroxyl Radicals in Living Cells . Sensors & Actuators: B. Chemical, 2019, 284, 744-750. .DOI: 10.1016/j.snb.2018.12.163.

  5. Cíntia de Almeida Gonçalves, Rute Cunha Figueiredo, Alessandra Giani, Daniel Collado, Ezequiel Pérez-Inestrosa, Javier Rojo, Cleber Cunha Figueredo. Detection of glycidic receptors in microalgae using glycodendrons as probes: a new tool for studies on cell surface interactions . Journal of Applied Phycology, 2018, accepted. DOI: 10.1007/s10811-018-1555-6

  6. Noemi Molina, Angela Martin-Serrano, Tahia D. Fernandez, Amene Tesfaye, Francisco Najera, Maria J. Torres, Cristobalina Mayorga, Yolanda Vida, Maria I. Montañez, Ezequiel Perez-Inestrosa. Dendrimeric Antigens for Drug Allergy Diagnosis: A New Approach for Basophil Activation Tests  Molecules, 2018, 23 (5), 997.  DOI: 10.3390/molecules23050997

  7. Ignasi Casanellas, Anna Lagunas, Iro Tsintzou, Yolanda Vida, Daniel Collado, Ezequiel Pérez-Inestrosa, Cristina Rodríguez-Pereira, Joana Magalhaes, Pau Gorostiza, José A. Andrades, José Becerra, Josep Samitier. Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation  Journal of Visualized Experiments, 2018, 131, e56347.  DOI: 10.3791/56347

Grupo de Química Orgánica Farmacéutica (POC)

  1. Achelle, S.; Rodríguez-López, J.; Robin-le Guen, F. Photoluminescence Properties of Aryl-, Arylvinyl-, and Arylethynylpyrimidine Derivatives. ChemistrySelect 2018, 3, 1852- 1886.

  2. Castro-Osma, J. A.; Martínez, J.; de la Cruz-Martínez, F.; Caballero, M. P.; Fernández-Baeza, J.; Rodríguez-López, J; Otero, A.; Lara-Sánchez, A.; Tejeda, J.Development of hydroxy-containing imidazole organocatalysts for CO2 fixation into cyclic carbonates. Catal. Sci. Technol. 2018, 8,  1981-1987.              

  3. Tolosa, J.; Serrano de las Heras, G.; Carrión, B.; Segura, T.; Páez, P. L.; de Lera-Garrido, F. J.; Rodríguez-López, J.; García-Martínez, J. C. Structure-Activity Relationships for Poly(phenylene)vinylene Derivatives as Antibacterial Agents. ChemistrySelect, 2018,3, 7327-7332.               

  4. Domínguez, R.; Tolosa, J.; Moral, M.; Bravo, I.; Canales-Vázquez, J.; Rodríguez-López, J.; Garzón, A.; García-Martínez, J. C. pH-Controlled Self-Assembly of X-Shaped Conjugated Molecules: The Case of 1,2,4,5-Tetrastyrylbenzene. J. Phys. Chem. C 2018, 122, 19937-19945. 

  5. Mónica Moral, Rocío Domínguez, M. Paz Fernández-Liencres, Andrés Garzón-Ruiz , Joaquín C. García-Martínez, Amparo Navarro.“Photophysical features and semiconducting properties of propellershaped oligo(styryl)benzenes”  J. Chem. Phys. 2019,150, 064309.

  6. Rocío Domínguez, Juan Tolosa, Mónica Moral, Ivan Bravo, Jesus Canales-Vazquez, Julian Rodríguez-Lopez, Andres Garzon-Ruiz, Joaquín C. García-Martínez. “pH-Controlled Self-Assembly of X‑Shaped Conjugated Molecules: The Case of 1,2,4,5-Tetrastyrylbenzene” J. Phys. Chem. C 2018, 122, 19937–19945.

 

Grupo de Eduardo Fernandez-Megia

  1. Neira, J. L.; Correa, J.; Rizzuti, B.; Santofimia-Castaño, P.; Abian, O.; Velázquez-Campoy, A.; Fernandez-Megia, E.; Iovanna, J. L. Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1.Biomacromolecules 2019, 20, 2567.

  2. Lopez-Blanco, R.; Fernandez-Villamarin, M.; Jatunov, S.; Novoa-Carballal, R.; Fernandez-Megia, E. Polysaccharides meet dendrimers to fine-tune the stability and release properties of polyion complex micelles. Polym. Chem. 2019, 10, 4709-4717.

  3. Cruz, L.; Basílio, N.; Mendoza, J.; Mateus, N.; de Freitas, V.; Tawara, M. H.; Correa, J.; Fernandez-Megia, Impact of a Water-Soluble Gallic Acid-Based Dendrimer on the Color-Stabilizing Mechanisms of Anthocyanins. E. Chem. Eur. J. 2019, 25, 11696.

  4. Vukojicic, P.; Béhar, G.; Tawara, M. H.; Fernandez-Villamarin, M.; Pecorari, F.; Fernandez-Megia, E.; Mouratou, B. Multivalent Affidendrons with High Affinity and Specificity toward Staphylococcus aureus as Versatile Tools for Modulating Multicellular Behaviors. ACS Applied Materials & Interfaces 2019, 11, 21391.

  5. Correa, J.; Pinto, L. F.; Zhao, L.; Riguera, R.; Fernandez-Megia, E. Filtering the NMR Spectra of Complex Mixtures through Polymer-Mediated Paramagnetic Spin Relaxation. Chem. Eur. J. 2018, 24, 19236-19242.

  6. Pinto, L. F.; Correa, J.; Zhao, L.; Riguera, R.; Fernandez-Megia, E. Fast NMR Screening of Macromolecular Complexes by a Paramagnetic Spin Relaxation Filter. ACS Omega 2018, 3, 2974-2983.

  7. Amaral, S. P.; Tawara, M. H.; Fernandez-Villamarin, M.; Borrajo, E.; Martínez-Costas, J.; Vidal, A.; Riguera, R.; Fernandez-Megia, E. Tuning the Size of Nanoassembles: A Hierarchical Transfer of Information from Dendrimers to Polyion Complexes. Angew. Chem., Int. Ed. 2018, 57, 5273-5277.

  8. Yemisci, M.; Caban, S.; Fernandez-Megia, E.; Capan, Y.; Couvreur, P.; Dalkara, T. Preparation and Characterization of Biocompatible Chitosan Nanoparticles for Targeted Brain Delivery of Peptides. In Neurotrophic Factors: Methods and Protocols; Skaper, Ed.; Springer New York: New York, NY, 2018, p 443-454.P

Grupo Laboratorio Inmuno-Biología Molecular. Aplicaciones Biomédicas de Nanopartículas.

  1. Benito JM, Ortiz MC, León A, Sarabia LA, Ligos JM, Montoya M, Garcia M, Ruiz-Mateos E, Palacios R, Cabello A, Restrepo C, Rodriguez C, Del Romero J, Leal M, Muñoz-Fernández MA, Alcamí J, García F, Górgolas M, Rallón N; ECRIS integrated in the Spanish AIDS Research Network. Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers. BMC Med. 2018 Feb 28;16(1):30. 

  2. Sánchez-Milla M, Pastor I, Maly M, Serramía MJ, Gómez R, Sánchez-Nieves J, Ritort F, Muñoz-Fernández MÁ, de la Mata FJ. Study of non-covalent interactions on dendriplex formation: influence of hydrophobic, electrostatic and hydrogen bonds interactions. Colloids Surf B Biointerfaces. 2018 Feb 1;162:380-388. 

  3. Ezequiel Ruiz-Mateos, Laura Tarancon-Diez, Ana I. Alvarez-Ríos, Beatriz Dominguez-Molina Migue Genebat, Ildefonso Pulido, Maria Antonia Abad, Mª Angeles Muñoz-Fernández, Manuel Leal. Association of heterozygous CCR5Δ32 deletion with survival in HIV-infection: A cohort study. Antiviral Res. 2018 Feb;150:15-19. 

  4. Guardo AC, Gómez CE, Díaz-Brito V, Pich J, Arnaiz JA, Perdiguero B, García-Arriaza J, González N, Sorzano COS, Jiménez L, Jiménez JL, Muñoz-Fernández MÁ, Gatell JM, Alcamí J, Esteban M, de Quirós JCLB, García F, Plana M; RISVAC02boost study. Correction: Safety and vaccine-induced HIV-1 immune responses in healthy volunteers following a late MVA-B boost 4 years after the last immunization. PLoS One. 2018 Apr 10;13(4):e0195915. 

  5. María Isabel Gonzalez-Tomé, Cristina García-Navarro, Beatriz Ruiz-Saez, Talía Sainz, Santiago Jiménez de Ory, Pablo Rojo, María José Mellado Peña, Luiz Prieto, Mª Angeles Muñoz-Fernández, Bearta, Zamora et al. Sleep Profile and Self-Reported Neuropsychiatric Symptoms in Vertically HIV-Infected Adolescents on cART.  J Pediatr Infect Dis. 2018; Abril 13(04): 300-307.

  6. Salinas-Muñoz L, Campos-Fernández R, Mercader E, Olivera-Valle I, Fernández-Pacheco C, Matilla L, García-Bordas J, Brazil JC, Parkos CA, Asensio F, Muñoz-Fernández MA, Hidalgo A, Sánchez-Mateos P, Samaniego R, Relloso M. Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to Candida albicans. Front Immunol. 2018 May 24;9:1033.  

  7. Sepúlveda-Crespo D, de la Mata FJ, Gómez R, Muñoz-Fernández MA. Sulfonate-ended carbosilane dendrimers with a flexible scaffold cause inactivation of HIV-1 virions and gp120 shedding. Nanoscale. 2018 May 17;10(19):8998-9011. .

  8. Bártolo I, Diniz AR, Borrego P, Ferreira JP, Bronze MR, Barroso H, Pinto R, Cardoso C, Pinto JF, Diaz RC, Broncano PG, Muñoz-Fernández MA, Taveira N. Correction: Evaluation of the fusion inhibitor P3 peptide as a potential microbicide to prevent HIV transmission in women. PLoS One. 2018 May 2;13(5):e0197015. eCollection 2018. Erratum in: PLoS One. 2018 Apr 18;13(4):e0195744. 

  9. Tarancon-Diez L, De Pablo-Bernal RS, Jiménez JL, Álvarez-Ríos AI, Genebat M, Rosado-Sánchez I, Muñoz-Fernández MÁ, Ruiz-Mateos E, Leal M. Role of toll-like receptor 4 Asp299Gly polymorphism in the development of cardiovascular diseases in HIV-infected patients. AIDS. 2018 May 15;32(8):1035-1041. 

  10. Guerrero-Beltran C, Rodriguez-Izquierdo I, Serramia MJ, Araya-Durán I, Márquez-Miranda V, Gomez R, de la Mata FJ, Leal M, González-Nilo F, Muñoz-Fernández MA. Anionic Carbosilane Dendrimers Destabilize the GP120-CD4 Complex Blocking HIV-1 Entry and Cell to Cell Fusion. Bioconjug Chem. 2018 May 16;29(5):1584-1594. I

  11. Gutiérrez-Rivas M, Jiménez-Sousa MÁ, Rallón N, Jiménez JL, Restrepo C, León A, Montero-Alonso M, González-García J, Muñoz-Fernández MÁ, Benito JM, Resino S; ECRIS Integrated in the Spanish AIDS Research Network. High Plasma Levels of sTNF-R1 and CCL11 Are Related to CD4+ T-Cells Fall in Human Immunodeficiency Virus Elite Controllers With a Sustained Virologic Control. Front Immunol. 2018 Jun 18;9:1399.

  12. Medrano LM, Garcia-Broncano P, Berenguer J, González-García J, Jiménez-Sousa MÁ, Guardiola JM, Crespo M, Quereda C, Sanz J, Canorea I, Carrero A, Hontañón V, Muñoz-Fernández MÁ, Resino S; GESIDA 3603b Study Group. Elevated liver stiffness is linked to increased biomarkers of inflammation and immune activation in HIV/hepatitis C virus-coinfected patients. AIDS. 2018 Jun 1;32(9):1095-1105. 

  13. Rosado-Sánchez I, Herrero-Fernández I, Genebat M, Del Romero J, Riera M, Podzamczer D, Olalla J, Vidal F, Muñoz-Fernández MA, Leal M, Pacheco YM. HIV-Infected Subjects With Poor CD4 T-Cell Recovery Despite Effective Therapy Express High Levels of OX40 and α4β7 on CD4 T-Cells Prior Therapy Initiation. Front Immunol. 2018 Jul 18;9:1673. e

  14. Puertas MC, Gómez-Mora E, Santos JR, Moltó J, Urrea V, Morón-López S, Hernández-Rodríguez A, Marfil S, Martínez-Bonet M, Matas L, Muñoz-Fernández MA, Clotet B, Blanco J, Martinez-Picado J. Impact of intensification with raltegravir on HIV-1-infected individuals receiving monotherapy with boosted PIs. J Antimicrob Chemother. 2018 Jul; 73(7): 1940–1948. 

  15. Correa-Rocha R, Lopez-Abente J, Gutierrez C, Pérez-Fernández VA, Prieto-Sánchez A, Moreno-Guillen S, Muñoz-Fernández MÁ, Pion M. CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion. PLoS One. 2018 Aug 30;13(8):e0203419. 

  16. Lopez-Abente J, Prieto-Sanchez A, Muñoz-Fernandez MÁ, Correa-Rocha R, Pion M. Human immunodeficiciency virus type-1 induces a regultaory B cell-like phenotype in vitro. Cell Mol Immunol. 2018 Oct;15(10):917-933.

  17. Tagarro A, Chan M, Zangari P, Ferns B, Foster C, De Rossi A, Nastouli E, Muñoz-Fernández MA, Gibb D, Rossi P, Giaquinto C, Babiker A, Fortuny C, Freguja R, Cotugno N, Judd A, Noguera-Julian A, Navarro ML, Mellado MJ, Klein N, Palma P, Rojo P. Early and Highly Suppressive Antiretroviral Therapy Are Main Factors Associated With Low Viral Reservoir in European Perinatally HIV-Infected Children. J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):269-276. 

  18. Dominguez-Molina B, Ferrando-Martinez S, Tarancon-Diez L, Hernandez-Quero J, Genebat M, Vidal F, Muñoz-Fernandez MA, Leal M, Koup R, Ruiz-Mateos E. Immune Correlates of Natural HIV Elite Control and Simultaneous HCV Clearance-Supercontrollers. Front Immunol. 2018 Dec 10;9:2897. 

  19. Martínez-Bonet M, Muñoz-Fernández MA, Álvarez S. HIV-1 increases extracellular amyloid-beta levels through neprilysin regulation in primary cultures of human astrocytes. J Cell Physiol. 2019 May ;234(5):5880-5998.

Laboratorio de Radicales Orgánicos. NANOMOL.ICMAB.CSIC

  1. V. Lloveras, F. Liko, L. F. Pinto, J.L. Muñoz-Gómez, J. Veciana, J. Vidal-Gancedo. Tuning Spin-Spin Interactions in Radical Dendrimers. ChemPhysChem. 2018, 19, 1895-1902V.

  2. Lloveras, F. Liko, J. Veciana, J. L. Muñoz-Gómez, J. Vidal-Gancedo. “Redox active PTM radical dendrimers as promising multifunctional molecular switches.” Chem. Mater. 2019, 31, 9400-9412. DOI: 10.1021/acs.chemmater.9b0301

  3. L. Pinto, V. Lloveras, F. Liko, S. Zhang, J. Veciana, J.L. Muñoz-Gómez, J. Vidal-Gancedo.“Fully water-soluble polyphosphothydrazone-based radical dendrimers functionalized wit Tyr-PROXYL radical as metal-free MRI T1 contrast agents”. ACS Appl. Bio Mater. 2020, 3, 369−376. DOI: 10.1021/acsabm.9b0085

Results 2018-2019

 

BIONANODEN

  1. Cena-Diez, R.; Martin-Moreno, A.; de la Mata, F. J.; Gomez-Ramirez, R.; Munoz, E.; Ardoys, M.; Munoz-Fernandez, M. A.  G1-S4 or G2-S16 carbosilane dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity. Int. J. Nanomedicine 2019, 14,2371-2380.

  2. del Olmo, N. S.; Carloni, R.; Bajo, A. M.; Ortega, P.; Fattori, A.; Gomez, R.; Ottaviani, M. F.; Garcia-Gallego, S.; Cangiotti, M.; de la Mata, F. J.  Insight into the antitumor activity of carbosilane Cu(ii)-metallodendrimers through their interaction with biological membrane models. Nanoscale 2019, 11, (28),13330-13342.

  3. Fernandez, J.; Acosta, G.; Pulido, D.; Maly, M.; Copa-Patino, J. L.; Soliveri, J.; Royo, M.; Gomez, R.; Albericio, F.; Ortega, P.; de la Mata, F. J.  Carbosilane Dendron-Peptide Nanoconjugates as Antimicrobial Agents. Mol. Pharm. 2019, 16, (6),2661-2674.

  4.  Holota, M.; Magiera, J.; Michlewska, S.; Kubczak, M.; del Olmo, N. S.; Garcia-Gallego, S.; Ortega, P.; de la Mata, F. J.; Ionov, M.; Bryszewska, M.  In Vitro Anticancer Properties of Copper Metallodendrimers. Biomolecules 2019, 9, (4).

  5. Krasheninina, O. A.; Apartsin, E. K.; Fuentes, E.; Szulc, A.; Ionov, M.; Venyaminova, A. G.; Shcharbin, D.; de la Mata, F. J.; Bryszewska, M.; Gomez, R.  Complexes of Pro-Apoptotic siRNAs and Carbosilane Dendrimers: Formation and Effect on Cancer Cells. Pharmaceutics 2019, 11, (1).

  6. Maroto-Diaz, M.; del Olmo, N. S.; Munoz-Moreno, L.; Bajo, A. M.; Carmena, M. J.; Gomez, R.; Garcia-Gallego, S.; de la Mata, F. J.  In vitro and in vivo evaluation of first-generation carbosilane arene Ru(II)- metallodendrimers in advanced prostate cancer. European Polymer Journal 2019, 113,229-235.

  7. Martin-Perez, T.; Lozano-Cruz, T.; Criado-Fornelio, A.; Ortega, P.; Gomez, R.; de la Mata, F. J.; Perez-Serrano, J.  Synthesis and in vitro activity of new biguanide-containing dendrimers on pathogenic isolates of Acanthamoeba polyphaga and Acanthamoeba griffini. Parasitology Research 2019, 118, (6),1953-1961.

  8. Sanchez-Milla, M.; Munoz-Moreno, L.; Sanchez-Nieves, J.; Maly, M.; Gomez, R.; Carmena, M. J.; de la Mata, F. J.  Anticancer Activity of Dendriplexes against Advanced Prostate Cancer from Protumoral Peptides and Cationic Carbosilane Dendrimers. Biomacromolecules 2019, 20, (3),1224-1234.

  9. Vasquez-Villanueva, R.; Pena-Gonzalez, C. E.; Sanchez-Nieves, J.; de la Mata, F. J.; Marina, M. L.; Garcia, M. C.  Gold nanoparticles coated with carbosilane dendrons in protein sample preparation. Microchimica Acta 2019, 186, (8).

  10. Shcharbin, D  ; Pedziwiatr-Werbicka, E; Serchenya, T; Cyboran-Mikolajczyk, S; Prakhira, L; Abashkin, V; Dzmitruk, V; Lonov, M; Loznikova, S; Shyrochyna, L;  Sviridov, O; Pena-Gonzalez, CE ; Gumiel, AB ; Gomez, R; de la Mata, FJ; Bryszewska, M. Role of cationic carbosilane dendrons and metallic core of functionalized gold nanoparticles in their interaction with human serum albumin. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 118, 1773-1780  Subdivisión: B. DOI: 10.1016/j.ijbiomac.2018.07.023

  11. Lozano-Cruz, T ; Gomez, R; de la Mata, FJ ; Ortega, P. New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent. NEW JOURNAL OF CHEMISTRY 2018, 42 (14), 11732-11738. DOI: 10.1039/c8nj01713a

  12. Sepulveda-Crespo, D; de la Mata, FJ  ; Gómez, R  ; Muñoz-Fernandez, MA. Sutfonate-ended carbosilane dendrimers with a flexible scaffold cause inactivation of HIV-1 virions and gp120 shedding. NANOSCALE 2018, 10 (19), 8998-9011. DOI: 10.1039/c8nr01664j

  13. Guerrero-Beltran, C; Rodriguez-Izquierdo, I; Serramia, MJ; Araya-Duran, I; Marquez-Miranda, V  ; Gomez, R; de la Mata, FJ; Leal, M; Gonzalez-Nilo, F ; Muñoz-Fernandez, MA. Anionic Carbosilane Dendrimers Destabilize the GP120-CD4 Complex Blocking HIV-1 Entry and Cell to Cell Fusion. BIOCONJUGATE CHEMISTRY 2018, 29 (5), 1584-1594.DOI: 10.1021/acs.bioconjchem.8b00106.

  14. Michlewska, S; Ionov, M ; Maroto-Diaz, M; Szwed, A; Ihnatsyeu-Kachan, A; Loznikova, S; Shcharbin, D; Maly, M; Ramirez, RG; de la Mata, FJ; Bryszewska, M. Ruthenium dendrimers as carriers for anticancer siRNA. JOURNAL OF INORGANIC BIOCHEMISTRY, 2018, 181,18-27. DOI: 10.1016/j.jinorgbio.2018.01.001

  15. Heredero-Bermejo, I ; Hernandez-Ros, JM ; Sanchez-Garcia, L ; Maly, M ; Verdu-Exposito, C ; Soliveri, J ; de la Mata, FJ ; Copa-Patino, JL ; Perez-Serrano, J ; Sanchez-Nieves, J  , Gomez, R.  Ammonium and guanidine carbosilane dendrimers and dendrons as microbicides. EUROPEAN POLYMER JOURNAL, 2018,  101,  159-168. DOI: 10.1016/j.eurpolymj.2018.02.025

  16. Pedziwiatr-Werbicka, E; Serchenya, T; Shcharbin, D; Terekhova, M; Prokhira, E ; Dzmitruk, V; Shyrochyna, I; Sviridov, O; Pena-Gonzalez, CE; Gomez, R; Sanchez-Nieves, J ; de la Mata, FJ ; Bryszewska, M. Dendronization of gold nanoparticles decreases their effect on human alpha-1-microglobulin. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2018, 108, 936-941. DOI: 10.1016/j.ijbiomac.2017.11.004

  17. Sanchez-Milla, M  ; Pastor, I ; Maly, M ; Serramia, MJ ; Gomez, R  ; Sanchez-Nieves, J ; Ritort, F ; Muñoz-Fernandez, MA ; de la Mata, FJ. Study of non-covalent interactions on dendriplex formation: Influence of hydrophobic, electrostatic and hydrogen bonds interactions. COLLOIDS AND SURFACES B-BIOINTERFACES 2018, 162, 380-388. DOI: 10.1016/j.colsurfb.2017.12.009

  18. Gutierrez-Ulloa, CE ; Buyanova, MY ; Apartsin, EK ; Venyaminova, AGde la Mata, FJ ; Gomez, R. Carbon Nanotubes Decorated with Cationic Carbosilane Dendrons and Their Hybrids with Nucleic Acids. CHEMNANOMAT 2018,4 (2), 220-230. DOI: 10.1002/cnma.201700351

 

 

Grupo Laboratorio de Glicosistemas:

  1. Palomares, F.; Ramos-Soriano, J.; Gomez, F.; Mascaraque, A.; Bogas, G.; Richard Perkins, J.; Gonzalez, M.; Jose Torres, M.; Diaz-Perales, A.; Rojo, J.; Mayorga, C.  Pru p 3-Glycodendropeptides Based on Mannoses Promote Changes in the Immunological Properties of Dendritic and T-Cells from LTP-Allergic Patients. Molecular Nutrition & Food Research 2019, 63, (20).

  2. Ramos-Soriano, J.; Reina, J. J.; Illescas, B. M.; de la Cruz, N.; Rodriguez-Perez, L.; Lasala, F.; Rojo, J.; Delgado, R.; Martin, N.  Synthesis of Highly Efficient Multivalent Disaccharide/ 60 Fullerene Nanoballs for Emergent Viruses. Journal of the American Chemical Society 2019, 141, (38), 15403-15412.

  3. Rodriguez, M. J.; Ramos-Soriano, J.; Perkins, J. R.; Mascaraque, A.; Torres, M. J.; Gomez, F.; Diaz-Perales, A.; Rojo, J.; Mayorga, C.  Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model. Scientific Reports 2019, 9.

  4. Benede, S.; Ramos-Soriano, J.; Palomares, F.; Losada, J.; Mascaraque, A.; Carlos Lopez-Rodriguez, J.; Rojo, J.; Mayorga, C.; Villalba, M.; Batanero, E.  Peptide Glycodendrirners as Potential Vaccines for Olive Pollen Allergy. Molecular Pharmaceutics 2019, 17, (3), 827-836.

  5. Javier Ramos-Soriano, Jose Juan Reina, Beatriz M Illescas, Javier Rojo, and Nazario Martín. Maleimide and Cyclooctyne Based Hexakis-Adducts of Fullerene: Multivalent Scaffolds for Copper-Free Click Chemistry on Fullerenes. J. Org. Chem., 2018, 83, 1727−1736. DOI: 10.1021/acs.joc.7b02402

  6. Cíntia de Almeida Gonçalves, Rute Cunha Figueiredo, Alessandra Giani, Daniel Collado, Ezequiel Pérez-Inestrosa, Javier Rojo, Cleber Cunha Figueredo. Detection of glycidic receptors in microalgae using glycodendrons as probes: a new tool for studies on cell surface interactions. J. Appl. Phycol. 2018, DOI: 10.1007/s10811-018-1555-6

  7. Laura Rodríguez-Pérez, Javier Ramos-Soriano, Alfonso Pérez-Sánchez, Beatriz M. Illescas, Antonio Muñoz, Joanna Luczkowiak, Fátima Lasala, Javier Rojo, Rafael Delgado, and Nazario Martín. Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection. J. Am. Chem. Soc., 2018, 140, 9891-9898, DOI: 10.1021/jacs.8b03847

  8. Maria Jose Rodriguez, Francisca Palomares, Gador Bogas, Maria Jose Torres, Araceli Diaz-Perales, Javier Rojo, Maria del Carmen Plaza-Seron, Alba Rodriguez-Nogales, Christine Orengo, Cristobalina Mayorga,* and James Richard Perkins.Transcriptional Profiling of Dendritic Cells in a Mouse Model of Food-Antigen-Induced Anaphylaxis Reveals the Upregulation of Multiple Immune-Related PathwaysREF. REVISTA/LIBRO: Mol. Nut. Food Res. 2019, 63, DOI: 10.1002/mnfr.201800759

Laboratorio de Dendrímeros Biomiméticos y Fotónica (LDBF)

 

  1. Noemi Molina, Francisco Nájera, Juan A. Guadix, Jose M. Perez-Pomares, Yolanda Vida and Ezequiel Perez-Inestrosa. Synthesis of Amino Terminal Clicked dendrimers. Approaches to the application as a biomarker Journal of Organic Chemistry, 2019, 84 (16), 10197-10208. DOI: 10.1021/acs.joc.9b01369

  2. Noemi Molina; Marvin Cnudde; Juan A. Guadix; Jose M. Perez-Pomares; Cristian Strassert; Yolanda Vida; Ezequiel Perez-Inestrosa. A platinum-doped dendritic structure as a phosphorescent label for bacteria in two-photon excitation microscopy.  ACS Omega, 2019, 4 (8), 13027-13033.

  3. DOI: 10.1021/acsomega.9b0063

  4. Carlos Benitez-Martin, Juan A. Guadix, John R. Pearson, Francisco Najera, Jose M. Perez-Pomares, Ezequiel Perez-Inestrosa.  A Turn-On Two-Photon Fluorescent Probe for Detecting Lysosomal Hydroxyl Radicals in Living Cells . Sensors & Actuators: B. Chemical, 2019, 284, 744-750. .DOI: 10.1016/j.snb.2018.12.163.

  5. Cíntia de Almeida Gonçalves, Rute Cunha Figueiredo, Alessandra Giani, Daniel Collado, Ezequiel Pérez-Inestrosa, Javier Rojo, Cleber Cunha Figueredo. Detection of glycidic receptors in microalgae using glycodendrons as probes: a new tool for studies on cell surface interactions . Journal of Applied Phycology, 2018, accepted. DOI: 10.1007/s10811-018-1555-6

  6. Noemi Molina, Angela Martin-Serrano, Tahia D. Fernandez, Amene Tesfaye, Francisco Najera, Maria J. Torres, Cristobalina Mayorga, Yolanda Vida, Maria I. Montañez, Ezequiel Perez-Inestrosa. Dendrimeric Antigens for Drug Allergy Diagnosis: A New Approach for Basophil Activation Tests  Molecules, 2018, 23 (5), 997.  DOI: 10.3390/molecules23050997

  7. Ignasi Casanellas, Anna Lagunas, Iro Tsintzou, Yolanda Vida, Daniel Collado, Ezequiel Pérez-Inestrosa, Cristina Rodríguez-Pereira, Joana Magalhaes, Pau Gorostiza, José A. Andrades, José Becerra, Josep Samitier. Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation  Journal of Visualized Experiments, 2018, 131, e56347.  DOI: 10.3791/56347

Grupo de Química Orgánica Farmacéutica (POC)

  1. Achelle, S.; Rodríguez-López, J.; Robin-le Guen, F. Photoluminescence Properties of Aryl-, Arylvinyl-, and Arylethynylpyrimidine Derivatives. ChemistrySelect 2018, 3, 1852- 1886.

  2. Castro-Osma, J. A.; Martínez, J.; de la Cruz-Martínez, F.; Caballero, M. P.; Fernández-Baeza, J.; Rodríguez-López, J; Otero, A.; Lara-Sánchez, A.; Tejeda, J.Development of hydroxy-containing imidazole organocatalysts for CO2 fixation into cyclic carbonates. Catal. Sci. Technol. 2018, 8,  1981-1987.              

  3. Tolosa, J.; Serrano de las Heras, G.; Carrión, B.; Segura, T.; Páez, P. L.; de Lera-Garrido, F. J.; Rodríguez-López, J.; García-Martínez, J. C. Structure-Activity Relationships for Poly(phenylene)vinylene Derivatives as Antibacterial Agents. ChemistrySelect, 2018,3, 7327-7332.               

  4. Domínguez, R.; Tolosa, J.; Moral, M.; Bravo, I.; Canales-Vázquez, J.; Rodríguez-López, J.; Garzón, A.; García-Martínez, J. C. pH-Controlled Self-Assembly of X-Shaped Conjugated Molecules: The Case of 1,2,4,5-Tetrastyrylbenzene. J. Phys. Chem. C 2018, 122, 19937-19945. 

  5. Mónica Moral, Rocío Domínguez, M. Paz Fernández-Liencres, Andrés Garzón-Ruiz , Joaquín C. García-Martínez, Amparo Navarro.“Photophysical features and semiconducting properties of propellershaped oligo(styryl)benzenes”  J. Chem. Phys. 2019,150, 064309.

  6. Rocío Domínguez, Juan Tolosa, Mónica Moral, Ivan Bravo, Jesus Canales-Vazquez, Julian Rodríguez-Lopez, Andres Garzon-Ruiz, Joaquín C. García-Martínez. “pH-Controlled Self-Assembly of X‑Shaped Conjugated Molecules: The Case of 1,2,4,5-Tetrastyrylbenzene” J. Phys. Chem. C 2018, 122, 19937–19945.

 

Grupo de Eduardo Fernandez-Megia

  1. Neira, J. L.; Correa, J.; Rizzuti, B.; Santofimia-Castaño, P.; Abian, O.; Velázquez-Campoy, A.; Fernandez-Megia, E.; Iovanna, J. L. Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1.Biomacromolecules 2019, 20, 2567.

  2. Lopez-Blanco, R.; Fernandez-Villamarin, M.; Jatunov, S.; Novoa-Carballal, R.; Fernandez-Megia, E. Polysaccharides meet dendrimers to fine-tune the stability and release properties of polyion complex micelles. Polym. Chem. 2019, 10, 4709-4717.

  3. Cruz, L.; Basílio, N.; Mendoza, J.; Mateus, N.; de Freitas, V.; Tawara, M. H.; Correa, J.; Fernandez-Megia, Impact of a Water-Soluble Gallic Acid-Based Dendrimer on the Color-Stabilizing Mechanisms of Anthocyanins. E. Chem. Eur. J. 2019, 25, 11696.

  4. Vukojicic, P.; Béhar, G.; Tawara, M. H.; Fernandez-Villamarin, M.; Pecorari, F.; Fernandez-Megia, E.; Mouratou, B. Multivalent Affidendrons with High Affinity and Specificity toward Staphylococcus aureus as Versatile Tools for Modulating Multicellular Behaviors. ACS Applied Materials & Interfaces 2019, 11, 21391.

  5. Correa, J.; Pinto, L. F.; Zhao, L.; Riguera, R.; Fernandez-Megia, E. Filtering the NMR Spectra of Complex Mixtures through Polymer-Mediated Paramagnetic Spin Relaxation. Chem. Eur. J. 2018, 24, 19236-19242.

  6. Pinto, L. F.; Correa, J.; Zhao, L.; Riguera, R.; Fernandez-Megia, E. Fast NMR Screening of Macromolecular Complexes by a Paramagnetic Spin Relaxation Filter. ACS Omega 2018, 3, 2974-2983.

  7. Amaral, S. P.; Tawara, M. H.; Fernandez-Villamarin, M.; Borrajo, E.; Martínez-Costas, J.; Vidal, A.; Riguera, R.; Fernandez-Megia, E. Tuning the Size of Nanoassembles: A Hierarchical Transfer of Information from Dendrimers to Polyion Complexes. Angew. Chem., Int. Ed. 2018, 57, 5273-5277.

  8. Yemisci, M.; Caban, S.; Fernandez-Megia, E.; Capan, Y.; Couvreur, P.; Dalkara, T. Preparation and Characterization of Biocompatible Chitosan Nanoparticles for Targeted Brain Delivery of Peptides. In Neurotrophic Factors: Methods and Protocols; Skaper, Ed.; Springer New York: New York, NY, 2018, p 443-454.P

 

Cristales Líquidos y Polímeros

  1. Sierra, T., Dortez, S., Gonzalez, M. C., Palomares, F. J., Crevillen, A. G., and Escarpa, A.  Disposable carbon nanotube scaffold films for fast and reliable assessment of total (1)-acid glycoprotein in human serum using adsorptive transfer stripping square wave voltammetry, Analytical and Bioanalytical Chemistry 2019.DOI 10.1007/s00216-018-1419-6

  2. Fedeli, E., Lancelot, A., Dominguez, J. M., Serrano, J. L., Calvo, P., and Sierra, T.  Self-Assembling Hybrid Linear-Dendritic Block Copolymers: The Design of Nano-Carriers for Lipophilic Antitumoral Drugs, Nanomaterials 2019.DOI10.3390/nano9020161

  3. Coma-Cros, E. M., Lancelot, A., San Anselmo, M., Borgheti-Cardoso, L. N., Valle-Delgado, J. J., Serrano, J. L., Fernandez-Busquets, X., and Sierra, T.  Micelle carriers based on dendritic macromolecules containing bis-MPA and glycine for antimalarial drug delivery, Biomaterials Science 2019.DOI 10.1039/c8bm01600c

  4. Castillo-Valles, M., Beltran, E., Cerda, J., Arago, J., Romero, P., Serrano, J. L., Orti, E., Gimenez, R., and Sierra, T.  Self-Assembly of Clicked Star-Shaped Triazines into Functional Nanostructures, Chemnanomat 2019.DOI 10.1002/cnma.201800484

  5. Lancelot, A., Gonzalez-Pastor, R., Claveria-Gimeno, R., Romero, P., Abian, O., Martin-Duque, P., Serrano, J. L., and Sierra, T.  Cationic poly(ester amide) dendrimers: alluring materials for biomedical applications, Journal of Materials Chemistry B 2018.DOI 10.1039/c8tb00639c

Grupo de Macromoléculas Organometálicas Electroactivas (GMOE)

  1. Ospina, E., Casado, C. M., Alonso, B., and Armada, M. P. G.  Thiolated DAB Dendrimers-Gold Nanoparticles as Self-Assembled Layers for the Direct Electrochemistry of HRP, Journal of the Electrochemical Society 2019. DOI 10.1149/2.0411915jes

  2. Fernandez, L., Herrero, M., Alonso, B., Casado, C. M., and Armada, M. P. G.  Three-dimensional electrocatalytic surface based on an octasilsesquioxane dendrimer for sensing applications, Journal of Electroanalytical Chemistry 2019. DOI 10.1016/j.jelechem.2019.03.010

  3. Villena, C., Punjabi, D., Casado, C. M., Alonso, B., Losada, J., and Armada, M. P. G.  Monodispersed Size-Controlled Gold Nanoparticles from Electrodeposited Aminoferrocenyl Dendrimer-Templates and Their Application as Efficient Hydrogen Peroxide Electrocatalyst, Journal of the Electrochemical Society 2018.DOI 10.1149/2.1301807jes

 

Grupo Laboratorio Inmuno-Biología Molecular. Aplicaciones Biomédicas de Nanopartículas.

  1. Benito JM, Ortiz MC, León A, Sarabia LA, Ligos JM, Montoya M, Garcia M, Ruiz-Mateos E, Palacios R, Cabello A, Restrepo C, Rodriguez C, Del Romero J, Leal M, Muñoz-Fernández MA, Alcamí J, García F, Górgolas M, Rallón N; ECRIS integrated in the Spanish AIDS Research Network. Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers. BMC Med. 2018 Feb 28;16(1):30. 

  2. Sánchez-Milla M, Pastor I, Maly M, Serramía MJ, Gómez R, Sánchez-Nieves J, Ritort F, Muñoz-Fernández MÁ, de la Mata FJ. Study of non-covalent interactions on dendriplex formation: influence of hydrophobic, electrostatic and hydrogen bonds interactions. Colloids Surf B Biointerfaces. 2018 Feb 1;162:380-388. 

  3. Ezequiel Ruiz-Mateos, Laura Tarancon-Diez, Ana I. Alvarez-Ríos, Beatriz Dominguez-Molina Migue Genebat, Ildefonso Pulido, Maria Antonia Abad, Mª Angeles Muñoz-Fernández, Manuel Leal. Association of heterozygous CCR5Δ32 deletion with survival in HIV-infection: A cohort study. Antiviral Res. 2018 Feb;150:15-19. 

  4. Guardo AC, Gómez CE, Díaz-Brito V, Pich J, Arnaiz JA, Perdiguero B, García-Arriaza J, González N, Sorzano COS, Jiménez L, Jiménez JL, Muñoz-Fernández MÁ, Gatell JM, Alcamí J, Esteban M, de Quirós JCLB, García F, Plana M; RISVAC02boost study. Correction: Safety and vaccine-induced HIV-1 immune responses in healthy volunteers following a late MVA-B boost 4 years after the last immunization. PLoS One. 2018 Apr 10;13(4):e0195915. 

  5. María Isabel Gonzalez-Tomé, Cristina García-Navarro, Beatriz Ruiz-Saez, Talía Sainz, Santiago Jiménez de Ory, Pablo Rojo, María José Mellado Peña, Luiz Prieto, Mª Angeles Muñoz-Fernández, Bearta, Zamora et al. Sleep Profile and Self-Reported Neuropsychiatric Symptoms in Vertically HIV-Infected Adolescents on cART.  J Pediatr Infect Dis. 2018; Abril 13(04): 300-307.

  6. Salinas-Muñoz L, Campos-Fernández R, Mercader E, Olivera-Valle I, Fernández-Pacheco C, Matilla L, García-Bordas J, Brazil JC, Parkos CA, Asensio F, Muñoz-Fernández MA, Hidalgo A, Sánchez-Mateos P, Samaniego R, Relloso M. Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to Candida albicans. Front Immunol. 2018 May 24;9:1033.  

  7. Sepúlveda-Crespo D, de la Mata FJ, Gómez R, Muñoz-Fernández MA. Sulfonate-ended carbosilane dendrimers with a flexible scaffold cause inactivation of HIV-1 virions and gp120 shedding. Nanoscale. 2018 May 17;10(19):8998-9011. .

  8. Bártolo I, Diniz AR, Borrego P, Ferreira JP, Bronze MR, Barroso H, Pinto R, Cardoso C, Pinto JF, Diaz RC, Broncano PG, Muñoz-Fernández MA, Taveira N. Correction: Evaluation of the fusion inhibitor P3 peptide as a potential microbicide to prevent HIV transmission in women. PLoS One. 2018 May 2;13(5):e0197015. eCollection 2018. Erratum in: PLoS One. 2018 Apr 18;13(4):e0195744. 

  9. Tarancon-Diez L, De Pablo-Bernal RS, Jiménez JL, Álvarez-Ríos AI, Genebat M, Rosado-Sánchez I, Muñoz-Fernández MÁ, Ruiz-Mateos E, Leal M. Role of toll-like receptor 4 Asp299Gly polymorphism in the development of cardiovascular diseases in HIV-infected patients. AIDS. 2018 May 15;32(8):1035-1041. 

  10. Guerrero-Beltran C, Rodriguez-Izquierdo I, Serramia MJ, Araya-Durán I, Márquez-Miranda V, Gomez R, de la Mata FJ, Leal M, González-Nilo F, Muñoz-Fernández MA. Anionic Carbosilane Dendrimers Destabilize the GP120-CD4 Complex Blocking HIV-1 Entry and Cell to Cell Fusion. Bioconjug Chem. 2018 May 16;29(5):1584-1594. I

  11. Gutiérrez-Rivas M, Jiménez-Sousa MÁ, Rallón N, Jiménez JL, Restrepo C, León A, Montero-Alonso M, González-García J, Muñoz-Fernández MÁ, Benito JM, Resino S; ECRIS Integrated in the Spanish AIDS Research Network. High Plasma Levels of sTNF-R1 and CCL11 Are Related to CD4+ T-Cells Fall in Human Immunodeficiency Virus Elite Controllers With a Sustained Virologic Control. Front Immunol. 2018 Jun 18;9:1399.

  12. Medrano LM, Garcia-Broncano P, Berenguer J, González-García J, Jiménez-Sousa MÁ, Guardiola JM, Crespo M, Quereda C, Sanz J, Canorea I, Carrero A, Hontañón V, Muñoz-Fernández MÁ, Resino S; GESIDA 3603b Study Group. Elevated liver stiffness is linked to increased biomarkers of inflammation and immune activation in HIV/hepatitis C virus-coinfected patients. AIDS. 2018 Jun 1;32(9):1095-1105. 

  13. Rosado-Sánchez I, Herrero-Fernández I, Genebat M, Del Romero J, Riera M, Podzamczer D, Olalla J, Vidal F, Muñoz-Fernández MA, Leal M, Pacheco YM. HIV-Infected Subjects With Poor CD4 T-Cell Recovery Despite Effective Therapy Express High Levels of OX40 and α4β7 on CD4 T-Cells Prior Therapy Initiation. Front Immunol. 2018 Jul 18;9:1673. e

  14. Puertas MC, Gómez-Mora E, Santos JR, Moltó J, Urrea V, Morón-López S, Hernández-Rodríguez A, Marfil S, Martínez-Bonet M, Matas L, Muñoz-Fernández MA, Clotet B, Blanco J, Martinez-Picado J. Impact of intensification with raltegravir on HIV-1-infected individuals receiving monotherapy with boosted PIs. J Antimicrob Chemother. 2018 Jul; 73(7): 1940–1948. 

  15. Correa-Rocha R, Lopez-Abente J, Gutierrez C, Pérez-Fernández VA, Prieto-Sánchez A, Moreno-Guillen S, Muñoz-Fernández MÁ, Pion M. CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion. PLoS One. 2018 Aug 30;13(8):e0203419. 

  16. Lopez-Abente J, Prieto-Sanchez A, Muñoz-Fernandez MÁ, Correa-Rocha R, Pion M. Human immunodeficiciency virus type-1 induces a regultaory B cell-like phenotype in vitro. Cell Mol Immunol. 2018 Oct;15(10):917-933.

  17. Tagarro A, Chan M, Zangari P, Ferns B, Foster C, De Rossi A, Nastouli E, Muñoz-Fernández MA, Gibb D, Rossi P, Giaquinto C, Babiker A, Fortuny C, Freguja R, Cotugno N, Judd A, Noguera-Julian A, Navarro ML, Mellado MJ, Klein N, Palma P, Rojo P. Early and Highly Suppressive Antiretroviral Therapy Are Main Factors Associated With Low Viral Reservoir in European Perinatally HIV-Infected Children. J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):269-276. 

  18. Dominguez-Molina B, Ferrando-Martinez S, Tarancon-Diez L, Hernandez-Quero J, Genebat M, Vidal F, Muñoz-Fernandez MA, Leal M, Koup R, Ruiz-Mateos E. Immune Correlates of Natural HIV Elite Control and Simultaneous HCV Clearance-Supercontrollers. Front Immunol. 2018 Dec 10;9:2897. 

  19. Martínez-Bonet M, Muñoz-Fernández MA, Álvarez S. HIV-1 increases extracellular amyloid-beta levels through neprilysin regulation in primary cultures of human astrocytes. J Cell Physiol. 2019 May ;234(5):5880-5998.

Laboratorio de Radicales Orgánicos. NANOMOL.ICMAB.CSIC

  1. V. Lloveras, F. Liko, L. F. Pinto, J.L. Muñoz-Gómez, J. Veciana, J. Vidal-Gancedo. Tuning Spin-Spin Interactions in Radical Dendrimers. ChemPhysChem. 2018, 19, 1895-1902V.

  2. Lloveras, F. Liko, J. Veciana, J. L. Muñoz-Gómez, J. Vidal-Gancedo. “Redox active PTM radical dendrimers as promising multifunctional molecular switches.” Chem. Mater. 2019, 31, 9400-9412. DOI: 10.1021/acs.chemmater.9b0301

  3. L. Pinto, V. Lloveras, F. Liko, S. Zhang, J. Veciana, J.L. Muñoz-Gómez, J. Vidal-Gancedo.“Fully water-soluble polyphosphothydrazone-based radical dendrimers functionalized wit Tyr-PROXYL radical as metal-free MRI T1 contrast agents”. ACS Appl. Bio Mater. 2020, 3, 369−376. DOI: 10.1021/acsabm.9b0085