Laboratorio de Radicales Orgánicos. NANOMOL.ICMAB.CSIC
Research lines
The objective of the Organic Radicals Laboratory is the design, synthesis and characterization of organic radicals and the study of the behavior of different types of molecules, dendrimers or materials based on them, focused on the study of the magnetic interactions between radicals and in their biomedical applications such as medical diagnosis or the development of biosensors.
1.- Radical Dendrimers as Contrast Agents for Magnetic Resonance Imaging (MRI). Synthesis of new contrast agents for MRI and the development of different types of biosensors based on these systems.
2.- Radicals as polarizing agents in Dynamic Nuclear Polarization (DNP) and their application in medical diagnosis.
3.- Gold nanoparticles as scaffold for anchoring organic radicals to study the magnetic interactions between radicals as well as their use as magnetic probes.
Researchers
José Vidal Gancedo Songbai Zhang
Vega Lloveras Monserrat M. Pilar Elías Rodríguez
Flonja Liko Néstor Murciano
Fundings (last 5 years selection)
1.- Developing New Contrast Agents for Magnetic Resonance Imaging. Smart FUNctional MATerials for Social Grand Challenges. Frontier Interdisciplinary Proyects 2018. (FUNMAT-FIP-2018). 2018-2019.
2.- DGICT-MINECO. Molecule-based materials and supramolecular organizations for therapy, diagnosis and tissue engineering”. MAT2016-80826-R (2017-2019).
3.- AGAUR. Grup de Recerca Consolidat: Materials Orgànics i Nanociència Molecular, ICMAB (CSIC)". Nº: 2017 SGR 918 (2017-2019)
4.- DGICT-MINECO. Bio- and electro-active molecule-based materials for improving health and societal wellbeing. BeWell. CTQ2013-40480-R (2015-2017)
5.- CSIC. Radicales y dendrímeros radicales para imagen de Resonancia Magnética Nuclear y otras aplicaciones bio. Nº: 201760E080 (2017-2019)
Publications (last selection 5 years)
1.- E. Badetti, V. Lloveras, J. L. Muñoz-Gómez, R. M. Sebastián, A. M. Caminade, J. P. Majoral, J. Veciana, J. Vidal-Gancedo. Radical Dendrimers: A Family of Five Generations of Phosphorus Dendrimers Functionalized with TEMPO Radicals. Macromolecules 2014, 47, 7717-7724.
2.- V. Lloveras, E. Badetti, K. Wurst, V. Chechik, J. Veciana, J. Vidal-Gancedo. Magnetic and Electrochemical Properties of a Diradical TEMPO-substituted Disulfide in Solution, in a Crystal and anchored on Au(111) forming a SAM. Chem. Eur. J. 2016, 22, 1805-1815.
3-V. Lloveras, E. Badetti, J. Veciana and J. Vidal-Gancedo.Dynamics of Intramolecular Spin Exchange Interaction of a Nitronyl Nitroxide Diradical in Solution and on Surfaces. Nanoscale 2016, 8, 5049-5058 .
4.- L. Pinto, I. Marín-Montesinos, V. Lloveras, J.L. Muñoz-Gómez, M. Pons, J. Veciana, J. Vidal-Gancedo. NMR signal enhancement > 50000 times in Fast Dissolution Dynamic Nuclear Polarization. Chem. Commun. 2017, 53, 3757-3760.
5.- V. Lloveras, F. Liko, L. F. Pinto, J.L. Muñoz-Gómez, J. Veciana, J. Vidal-Gancedo. Tuning Spin-Spin Interactions in Radical Dendrimers. ChemPhysChem. 2018, 19, 1895-1902.
International Collaborations
1.- Prof. Anne-Marie Caminade. Laboratoire de Chimie de Coordination-CNRS, Toulouse. Francia.
2.- Prof. Victor Chechik. The University of York. UK.
3.- Dr. Klaus Wurst. Universidad de Innsbruk. Austria.
4.- Prof. Cristiano Zonta. Universidad de Padova. Italia.
5.- Dr. Elena Badetti. Universidad de Venecia. Italia.
6.- Prof. Aharón Blank. Technion. Israel.
7.- Prof. Jens Anders. Universidad de Stuttgart. Germany.