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PUBLICATIONS

Results 2018-2019

 

BIONANODEN

  1. Cena-Diez, R.; Martin-Moreno, A.; de la Mata, F. J.; Gomez-Ramirez, R.; Munoz, E.; Ardoys, M.; Munoz-Fernandez, M. A.  G1-S4 or G2-S16 carbosilane dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity. Int. J. Nanomedicine 2019, 14,2371-2380.

  2. del Olmo, N. S.; Carloni, R.; Bajo, A. M.; Ortega, P.; Fattori, A.; Gomez, R.; Ottaviani, M. F.; Garcia-Gallego, S.; Cangiotti, M.; de la Mata, F. J.  Insight into the antitumor activity of carbosilane Cu(ii)-metallodendrimers through their interaction with biological membrane models. Nanoscale 2019, 11, (28),13330-13342.

  3. Fernandez, J.; Acosta, G.; Pulido, D.; Maly, M.; Copa-Patino, J. L.; Soliveri, J.; Royo, M.; Gomez, R.; Albericio, F.; Ortega, P.; de la Mata, F. J.  Carbosilane Dendron-Peptide Nanoconjugates as Antimicrobial Agents. Mol. Pharm. 2019, 16, (6),2661-2674.

  4.  Holota, M.; Magiera, J.; Michlewska, S.; Kubczak, M.; del Olmo, N. S.; Garcia-Gallego, S.; Ortega, P.; de la Mata, F. J.; Ionov, M.; Bryszewska, M.  In Vitro Anticancer Properties of Copper Metallodendrimers. Biomolecules 2019, 9, (4).

  5. Krasheninina, O. A.; Apartsin, E. K.; Fuentes, E.; Szulc, A.; Ionov, M.; Venyaminova, A. G.; Shcharbin, D.; de la Mata, F. J.; Bryszewska, M.; Gomez, R.  Complexes of Pro-Apoptotic siRNAs and Carbosilane Dendrimers: Formation and Effect on Cancer Cells. Pharmaceutics 2019, 11, (1).

  6. Maroto-Diaz, M.; del Olmo, N. S.; Munoz-Moreno, L.; Bajo, A. M.; Carmena, M. J.; Gomez, R.; Garcia-Gallego, S.; de la Mata, F. J.  In vitro and in vivo evaluation of first-generation carbosilane arene Ru(II)- metallodendrimers in advanced prostate cancer. European Polymer Journal 2019, 113,229-235.

  7. Martin-Perez, T.; Lozano-Cruz, T.; Criado-Fornelio, A.; Ortega, P.; Gomez, R.; de la Mata, F. J.; Perez-Serrano, J.  Synthesis and in vitro activity of new biguanide-containing dendrimers on pathogenic isolates of Acanthamoeba polyphaga and Acanthamoeba griffini. Parasitology Research 2019, 118, (6),1953-1961.

  8. Sanchez-Milla, M.; Munoz-Moreno, L.; Sanchez-Nieves, J.; Maly, M.; Gomez, R.; Carmena, M. J.; de la Mata, F. J.  Anticancer Activity of Dendriplexes against Advanced Prostate Cancer from Protumoral Peptides and Cationic Carbosilane Dendrimers. Biomacromolecules 2019, 20, (3),1224-1234.

  9. Vasquez-Villanueva, R.; Pena-Gonzalez, C. E.; Sanchez-Nieves, J.; de la Mata, F. J.; Marina, M. L.; Garcia, M. C.  Gold nanoparticles coated with carbosilane dendrons in protein sample preparation. Microchimica Acta 2019, 186, (8).

  10. Shcharbin, D  ; Pedziwiatr-Werbicka, E; Serchenya, T; Cyboran-Mikolajczyk, S; Prakhira, L; Abashkin, V; Dzmitruk, V; Lonov, M; Loznikova, S; Shyrochyna, L;  Sviridov, O; Pena-Gonzalez, CE ; Gumiel, AB ; Gomez, R; de la Mata, FJ; Bryszewska, M. Role of cationic carbosilane dendrons and metallic core of functionalized gold nanoparticles in their interaction with human serum albumin. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 118, 1773-1780  Subdivisión: B. DOI: 10.1016/j.ijbiomac.2018.07.023

  11. Lozano-Cruz, T ; Gomez, R; de la Mata, FJ ; Ortega, P. New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent. NEW JOURNAL OF CHEMISTRY 2018, 42 (14), 11732-11738. DOI: 10.1039/c8nj01713a

  12. Sepulveda-Crespo, D; de la Mata, FJ  ; Gómez, R  ; Muñoz-Fernandez, MA. Sutfonate-ended carbosilane dendrimers with a flexible scaffold cause inactivation of HIV-1 virions and gp120 shedding. NANOSCALE 2018, 10 (19), 8998-9011. DOI: 10.1039/c8nr01664j

  13. Guerrero-Beltran, C; Rodriguez-Izquierdo, I; Serramia, MJ; Araya-Duran, I; Marquez-Miranda, V  ; Gomez, R; de la Mata, FJ; Leal, M; Gonzalez-Nilo, F ; Muñoz-Fernandez, MA. Anionic Carbosilane Dendrimers Destabilize the GP120-CD4 Complex Blocking HIV-1 Entry and Cell to Cell Fusion. BIOCONJUGATE CHEMISTRY 2018, 29 (5), 1584-1594.DOI: 10.1021/acs.bioconjchem.8b00106.

  14. Michlewska, S; Ionov, M ; Maroto-Diaz, M; Szwed, A; Ihnatsyeu-Kachan, A; Loznikova, S; Shcharbin, D; Maly, M; Ramirez, RG; de la Mata, FJ; Bryszewska, M. Ruthenium dendrimers as carriers for anticancer siRNA. JOURNAL OF INORGANIC BIOCHEMISTRY, 2018, 181,18-27. DOI: 10.1016/j.jinorgbio.2018.01.001

  15. Heredero-Bermejo, I ; Hernandez-Ros, JM ; Sanchez-Garcia, L ; Maly, M ; Verdu-Exposito, C ; Soliveri, J ; de la Mata, FJ ; Copa-Patino, JL ; Perez-Serrano, J ; Sanchez-Nieves, J  , Gomez, R.  Ammonium and guanidine carbosilane dendrimers and dendrons as microbicides. EUROPEAN POLYMER JOURNAL, 2018,  101,  159-168. DOI: 10.1016/j.eurpolymj.2018.02.025

  16. Pedziwiatr-Werbicka, E; Serchenya, T; Shcharbin, D; Terekhova, M; Prokhira, E ; Dzmitruk, V; Shyrochyna, I; Sviridov, O; Pena-Gonzalez, CE; Gomez, R; Sanchez-Nieves, J ; de la Mata, FJ ; Bryszewska, M. Dendronization of gold nanoparticles decreases their effect on human alpha-1-microglobulin. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2018, 108, 936-941. DOI: 10.1016/j.ijbiomac.2017.11.004

  17. Sanchez-Milla, M  ; Pastor, I ; Maly, M ; Serramia, MJ ; Gomez, R  ; Sanchez-Nieves, J ; Ritort, F ; Muñoz-Fernandez, MA ; de la Mata, FJ. Study of non-covalent interactions on dendriplex formation: Influence of hydrophobic, electrostatic and hydrogen bonds interactions. COLLOIDS AND SURFACES B-BIOINTERFACES 2018, 162, 380-388. DOI: 10.1016/j.colsurfb.2017.12.009

  18. Gutierrez-Ulloa, CE ; Buyanova, MY ; Apartsin, EK ; Venyaminova, AG; de la Mata, FJ ; Gomez, R. Carbon Nanotubes Decorated with Cationic Carbosilane Dendrons and Their Hybrids with Nucleic Acids. CHEMNANOMAT 2018,4 (2), 220-230. DOI: 10.1002/cnma.201700351

 

 

Grupo Laboratorio de Glicosistemas:

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  1. Palomares, F.; Ramos-Soriano, J.; Gomez, F.; Mascaraque, A.; Bogas, G.; Richard Perkins, J.; Gonzalez, M.; Jose Torres, M.; Diaz-Perales, A.; Rojo, J.; Mayorga, C.  Pru p 3-Glycodendropeptides Based on Mannoses Promote Changes in the Immunological Properties of Dendritic and T-Cells from LTP-Allergic Patients. Molecular Nutrition & Food Research 2019, 63, (20).

  2. Ramos-Soriano, J.; Reina, J. J.; Illescas, B. M.; de la Cruz, N.; Rodriguez-Perez, L.; Lasala, F.; Rojo, J.; Delgado, R.; Martin, N.  Synthesis of Highly Efficient Multivalent Disaccharide/ 60 Fullerene Nanoballs for Emergent Viruses. Journal of the American Chemical Society 2019, 141, (38), 15403-15412.

  3. Rodriguez, M. J.; Ramos-Soriano, J.; Perkins, J. R.; Mascaraque, A.; Torres, M. J.; Gomez, F.; Diaz-Perales, A.; Rojo, J.; Mayorga, C.  Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model. Scientific Reports 2019, 9.

  4. Benede, S.; Ramos-Soriano, J.; Palomares, F.; Losada, J.; Mascaraque, A.; Carlos Lopez-Rodriguez, J.; Rojo, J.; Mayorga, C.; Villalba, M.; Batanero, E.  Peptide Glycodendrirners as Potential Vaccines for Olive Pollen Allergy. Molecular Pharmaceutics 2019, 17, (3), 827-836.

  5. Javier Ramos-Soriano, Jose Juan Reina, Beatriz M Illescas, Javier Rojo, and Nazario Martín. Maleimide and Cyclooctyne Based Hexakis-Adducts of Fullerene: Multivalent Scaffolds for Copper-Free Click Chemistry on Fullerenes. J. Org. Chem., 2018, 83, 1727−1736. DOI: 10.1021/acs.joc.7b02402

  6. Cíntia de Almeida Gonçalves, Rute Cunha Figueiredo, Alessandra Giani, Daniel Collado, Ezequiel Pérez-Inestrosa, Javier Rojo, Cleber Cunha Figueredo. Detection of glycidic receptors in microalgae using glycodendrons as probes: a new tool for studies on cell surface interactions. J. Appl. Phycol. 2018, DOI: 10.1007/s10811-018-1555-6

  7. Laura Rodríguez-Pérez, Javier Ramos-Soriano, Alfonso Pérez-Sánchez, Beatriz M. Illescas, Antonio Muñoz, Joanna Luczkowiak, Fátima Lasala, Javier Rojo, Rafael Delgado, and Nazario Martín. Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection. J. Am. Chem. Soc., 2018, 140, 9891-9898, DOI: 10.1021/jacs.8b03847

  8. Maria Jose Rodriguez, Francisca Palomares, Gador Bogas, Maria Jose Torres, Araceli Diaz-Perales, Javier Rojo, Maria del Carmen Plaza-Seron, Alba Rodriguez-Nogales, Christine Orengo, Cristobalina Mayorga,* and James Richard Perkins.Transcriptional Profiling of Dendritic Cells in a Mouse Model of Food-Antigen-Induced Anaphylaxis Reveals the Upregulation of Multiple Immune-Related PathwaysREF. REVISTA/LIBRO: Mol. Nut. Food Res. 2019, 63, DOI: 10.1002/mnfr.201800759

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Laboratorio de Dendrímeros Biomiméticos y Fotónica (LDBF)

 

  1. Noemi Molina, Francisco Nájera, Juan A. Guadix, Jose M. Perez-Pomares, Yolanda Vida and Ezequiel Perez-Inestrosa. Synthesis of Amino Terminal Clicked dendrimers. Approaches to the application as a biomarker Journal of Organic Chemistry, 2019, 84 (16), 10197-10208. DOI: 10.1021/acs.joc.9b01369

  2. Noemi Molina; Marvin Cnudde; Juan A. Guadix; Jose M. Perez-Pomares; Cristian Strassert; Yolanda Vida; Ezequiel Perez-Inestrosa. A platinum-doped dendritic structure as a phosphorescent label for bacteria in two-photon excitation microscopy.  ACS Omega, 2019, 4 (8), 13027-13033.

  3. DOI: 10.1021/acsomega.9b0063

  4. Carlos Benitez-Martin, Juan A. Guadix, John R. Pearson, Francisco Najera, Jose M. Perez-Pomares, Ezequiel Perez-Inestrosa.  A Turn-On Two-Photon Fluorescent Probe for Detecting Lysosomal Hydroxyl Radicals in Living Cells . Sensors & Actuators: B. Chemical, 2019, 284, 744-750. .DOI: 10.1016/j.snb.2018.12.163.

  5. Cíntia de Almeida Gonçalves, Rute Cunha Figueiredo, Alessandra Giani, Daniel Collado, Ezequiel Pérez-Inestrosa, Javier Rojo, Cleber Cunha Figueredo. Detection of glycidic receptors in microalgae using glycodendrons as probes: a new tool for studies on cell surface interactions . Journal of Applied Phycology, 2018, accepted. DOI: 10.1007/s10811-018-1555-6

  6. Noemi Molina, Angela Martin-Serrano, Tahia D. Fernandez, Amene Tesfaye, Francisco Najera, Maria J. Torres, Cristobalina Mayorga, Yolanda Vida, Maria I. Montañez, Ezequiel Perez-Inestrosa. Dendrimeric Antigens for Drug Allergy Diagnosis: A New Approach for Basophil Activation Tests  Molecules, 2018, 23 (5), 997.  DOI: 10.3390/molecules23050997

  7. Ignasi Casanellas, Anna Lagunas, Iro Tsintzou, Yolanda Vida, Daniel Collado, Ezequiel Pérez-Inestrosa, Cristina Rodríguez-Pereira, Joana Magalhaes, Pau Gorostiza, José A. Andrades, José Becerra, Josep Samitier. Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation  Journal of Visualized Experiments, 2018, 131, e56347.  DOI: 10.3791/56347

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Grupo de Química Orgánica Farmacéutica (POC)

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  1. Achelle, S.; Rodríguez-López, J.; Robin-le Guen, F. Photoluminescence Properties of Aryl-, Arylvinyl-, and Arylethynylpyrimidine Derivatives. ChemistrySelect 2018, 3, 1852- 1886.

  2. Castro-Osma, J. A.; Martínez, J.; de la Cruz-Martínez, F.; Caballero, M. P.; Fernández-Baeza, J.; Rodríguez-López, J; Otero, A.; Lara-Sánchez, A.; Tejeda, J.Development of hydroxy-containing imidazole organocatalysts for CO2 fixation into cyclic carbonates. Catal. Sci. Technol. 2018, 8,  1981-1987.              

  3. Tolosa, J.; Serrano de las Heras, G.; Carrión, B.; Segura, T.; Páez, P. L.; de Lera-Garrido, F. J.; Rodríguez-López, J.; García-Martínez, J. C. Structure-Activity Relationships for Poly(phenylene)vinylene Derivatives as Antibacterial Agents. ChemistrySelect, 2018,3, 7327-7332.               

  4. Domínguez, R.; Tolosa, J.; Moral, M.; Bravo, I.; Canales-Vázquez, J.; Rodríguez-López, J.; Garzón, A.; García-Martínez, J. C. pH-Controlled Self-Assembly of X-Shaped Conjugated Molecules: The Case of 1,2,4,5-Tetrastyrylbenzene. J. Phys. Chem. C 2018, 122, 19937-19945. 

  5. Mónica Moral, Rocío Domínguez, M. Paz Fernández-Liencres, Andrés Garzón-Ruiz , Joaquín C. García-Martínez, Amparo Navarro.“Photophysical features and semiconducting properties of propellershaped oligo(styryl)benzenes”  J. Chem. Phys. 2019,150, 064309.

  6. Rocío Domínguez, Juan Tolosa, Mónica Moral, Ivan Bravo, Jesus Canales-Vazquez, Julian Rodríguez-Lopez, Andres Garzon-Ruiz, Joaquín C. García-Martínez. “pH-Controlled Self-Assembly of X‑Shaped Conjugated Molecules: The Case of 1,2,4,5-Tetrastyrylbenzene” J. Phys. Chem. C 2018, 122, 19937–19945.

 

Grupo de Eduardo Fernandez-Megia

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  1. Neira, J. L.; Correa, J.; Rizzuti, B.; Santofimia-Castaño, P.; Abian, O.; Velázquez-Campoy, A.; Fernandez-Megia, E.; Iovanna, J. L. Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1.Biomacromolecules 2019, 20, 2567.

  2. Lopez-Blanco, R.; Fernandez-Villamarin, M.; Jatunov, S.; Novoa-Carballal, R.; Fernandez-Megia, E. Polysaccharides meet dendrimers to fine-tune the stability and release properties of polyion complex micelles. Polym. Chem. 2019, 10, 4709-4717.

  3. Cruz, L.; Basílio, N.; Mendoza, J.; Mateus, N.; de Freitas, V.; Tawara, M. H.; Correa, J.; Fernandez-Megia, Impact of a Water-Soluble Gallic Acid-Based Dendrimer on the Color-Stabilizing Mechanisms of Anthocyanins. E. Chem. Eur. J. 2019, 25, 11696.

  4. Vukojicic, P.; Béhar, G.; Tawara, M. H.; Fernandez-Villamarin, M.; Pecorari, F.; Fernandez-Megia, E.; Mouratou, B. Multivalent Affidendrons with High Affinity and Specificity toward Staphylococcus aureus as Versatile Tools for Modulating Multicellular Behaviors. ACS Applied Materials & Interfaces 2019, 11, 21391.

  5. Correa, J.; Pinto, L. F.; Zhao, L.; Riguera, R.; Fernandez-Megia, E. Filtering the NMR Spectra of Complex Mixtures through Polymer-Mediated Paramagnetic Spin Relaxation. Chem. Eur. J. 2018, 24, 19236-19242.

  6. Pinto, L. F.; Correa, J.; Zhao, L.; Riguera, R.; Fernandez-Megia, E. Fast NMR Screening of Macromolecular Complexes by a Paramagnetic Spin Relaxation Filter. ACS Omega 2018, 3, 2974-2983.

  7. Amaral, S. P.; Tawara, M. H.; Fernandez-Villamarin, M.; Borrajo, E.; Martínez-Costas, J.; Vidal, A.; Riguera, R.; Fernandez-Megia, E. Tuning the Size of Nanoassembles: A Hierarchical Transfer of Information from Dendrimers to Polyion Complexes. Angew. Chem., Int. Ed. 2018, 57, 5273-5277.

  8. Yemisci, M.; Caban, S.; Fernandez-Megia, E.; Capan, Y.; Couvreur, P.; Dalkara, T. Preparation and Characterization of Biocompatible Chitosan Nanoparticles for Targeted Brain Delivery of Peptides. In Neurotrophic Factors: Methods and Protocols; Skaper, Ed.; Springer New York: New York, NY, 2018, p 443-454.P

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Grupo Laboratorio Inmuno-Biología Molecular. Aplicaciones Biomédicas de Nanopartículas.

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  1. Benito JM, Ortiz MC, León A, Sarabia LA, Ligos JM, Montoya M, Garcia M, Ruiz-Mateos E, Palacios R, Cabello A, Restrepo C, Rodriguez C, Del Romero J, Leal M, Muñoz-Fernández MA, Alcamí J, García F, Górgolas M, Rallón N; ECRIS integrated in the Spanish AIDS Research Network. Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers. BMC Med. 2018 Feb 28;16(1):30. 

  2. Sánchez-Milla M, Pastor I, Maly M, Serramía MJ, Gómez R, Sánchez-Nieves J, Ritort F, Muñoz-Fernández MÁ, de la Mata FJ. Study of non-covalent interactions on dendriplex formation: influence of hydrophobic, electrostatic and hydrogen bonds interactions. Colloids Surf B Biointerfaces. 2018 Feb 1;162:380-388. 

  3. Ezequiel Ruiz-Mateos, Laura Tarancon-Diez, Ana I. Alvarez-Ríos, Beatriz Dominguez-Molina Migue Genebat, Ildefonso Pulido, Maria Antonia Abad, Mª Angeles Muñoz-Fernández, Manuel Leal. Association of heterozygous CCR5Δ32 deletion with survival in HIV-infection: A cohort study. Antiviral Res. 2018 Feb;150:15-19. 

  4. Guardo AC, Gómez CE, Díaz-Brito V, Pich J, Arnaiz JA, Perdiguero B, García-Arriaza J, González N, Sorzano COS, Jiménez L, Jiménez JL, Muñoz-Fernández MÁ, Gatell JM, Alcamí J, Esteban M, de Quirós JCLB, García F, Plana M; RISVAC02boost study. Correction: Safety and vaccine-induced HIV-1 immune responses in healthy volunteers following a late MVA-B boost 4 years after the last immunization. PLoS One. 2018 Apr 10;13(4):e0195915. 

  5. María Isabel Gonzalez-Tomé, Cristina García-Navarro, Beatriz Ruiz-Saez, Talía Sainz, Santiago Jiménez de Ory, Pablo Rojo, María José Mellado Peña, Luiz Prieto, Mª Angeles Muñoz-Fernández, Bearta, Zamora et al. Sleep Profile and Self-Reported Neuropsychiatric Symptoms in Vertically HIV-Infected Adolescents on cART.  J Pediatr Infect Dis. 2018; Abril 13(04): 300-307.

  6. Salinas-Muñoz L, Campos-Fernández R, Mercader E, Olivera-Valle I, Fernández-Pacheco C, Matilla L, García-Bordas J, Brazil JC, Parkos CA, Asensio F, Muñoz-Fernández MA, Hidalgo A, Sánchez-Mateos P, Samaniego R, Relloso M. Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to Candida albicans. Front Immunol. 2018 May 24;9:1033.  

  7. Sepúlveda-Crespo D, de la Mata FJ, Gómez R, Muñoz-Fernández MA. Sulfonate-ended carbosilane dendrimers with a flexible scaffold cause inactivation of HIV-1 virions and gp120 shedding. Nanoscale. 2018 May 17;10(19):8998-9011. .

  8. Bártolo I, Diniz AR, Borrego P, Ferreira JP, Bronze MR, Barroso H, Pinto R, Cardoso C, Pinto JF, Diaz RC, Broncano PG, Muñoz-Fernández MA, Taveira N. Correction: Evaluation of the fusion inhibitor P3 peptide as a potential microbicide to prevent HIV transmission in women. PLoS One. 2018 May 2;13(5):e0197015. eCollection 2018. Erratum in: PLoS One. 2018 Apr 18;13(4):e0195744. 

  9. Tarancon-Diez L, De Pablo-Bernal RS, Jiménez JL, Álvarez-Ríos AI, Genebat M, Rosado-Sánchez I, Muñoz-Fernández MÁ, Ruiz-Mateos E, Leal M. Role of toll-like receptor 4 Asp299Gly polymorphism in the development of cardiovascular diseases in HIV-infected patients. AIDS. 2018 May 15;32(8):1035-1041. 

  10. Guerrero-Beltran C, Rodriguez-Izquierdo I, Serramia MJ, Araya-Durán I, Márquez-Miranda V, Gomez R, de la Mata FJ, Leal M, González-Nilo F, Muñoz-Fernández MA. Anionic Carbosilane Dendrimers Destabilize the GP120-CD4 Complex Blocking HIV-1 Entry and Cell to Cell Fusion. Bioconjug Chem. 2018 May 16;29(5):1584-1594. I

  11. Gutiérrez-Rivas M, Jiménez-Sousa MÁ, Rallón N, Jiménez JL, Restrepo C, León A, Montero-Alonso M, González-García J, Muñoz-Fernández MÁ, Benito JM, Resino S; ECRIS Integrated in the Spanish AIDS Research Network. High Plasma Levels of sTNF-R1 and CCL11 Are Related to CD4+ T-Cells Fall in Human Immunodeficiency Virus Elite Controllers With a Sustained Virologic Control. Front Immunol. 2018 Jun 18;9:1399.

  12. Medrano LM, Garcia-Broncano P, Berenguer J, González-García J, Jiménez-Sousa MÁ, Guardiola JM, Crespo M, Quereda C, Sanz J, Canorea I, Carrero A, Hontañón V, Muñoz-Fernández MÁ, Resino S; GESIDA 3603b Study Group. Elevated liver stiffness is linked to increased biomarkers of inflammation and immune activation in HIV/hepatitis C virus-coinfected patients. AIDS. 2018 Jun 1;32(9):1095-1105. 

  13. Rosado-Sánchez I, Herrero-Fernández I, Genebat M, Del Romero J, Riera M, Podzamczer D, Olalla J, Vidal F, Muñoz-Fernández MA, Leal M, Pacheco YM. HIV-Infected Subjects With Poor CD4 T-Cell Recovery Despite Effective Therapy Express High Levels of OX40 and α4β7 on CD4 T-Cells Prior Therapy Initiation. Front Immunol. 2018 Jul 18;9:1673. e

  14. Puertas MC, Gómez-Mora E, Santos JR, Moltó J, Urrea V, Morón-López S, Hernández-Rodríguez A, Marfil S, Martínez-Bonet M, Matas L, Muñoz-Fernández MA, Clotet B, Blanco J, Martinez-Picado J. Impact of intensification with raltegravir on HIV-1-infected individuals receiving monotherapy with boosted PIs. J Antimicrob Chemother. 2018 Jul; 73(7): 1940–1948. 

  15. Correa-Rocha R, Lopez-Abente J, Gutierrez C, Pérez-Fernández VA, Prieto-Sánchez A, Moreno-Guillen S, Muñoz-Fernández MÁ, Pion M. CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion. PLoS One. 2018 Aug 30;13(8):e0203419. 

  16. Lopez-Abente J, Prieto-Sanchez A, Muñoz-Fernandez MÁ, Correa-Rocha R, Pion M. Human immunodeficiciency virus type-1 induces a regultaory B cell-like phenotype in vitro. Cell Mol Immunol. 2018 Oct;15(10):917-933.

  17. Tagarro A, Chan M, Zangari P, Ferns B, Foster C, De Rossi A, Nastouli E, Muñoz-Fernández MA, Gibb D, Rossi P, Giaquinto C, Babiker A, Fortuny C, Freguja R, Cotugno N, Judd A, Noguera-Julian A, Navarro ML, Mellado MJ, Klein N, Palma P, Rojo P. Early and Highly Suppressive Antiretroviral Therapy Are Main Factors Associated With Low Viral Reservoir in European Perinatally HIV-Infected Children. J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):269-276. 

  18. Dominguez-Molina B, Ferrando-Martinez S, Tarancon-Diez L, Hernandez-Quero J, Genebat M, Vidal F, Muñoz-Fernandez MA, Leal M, Koup R, Ruiz-Mateos E. Immune Correlates of Natural HIV Elite Control and Simultaneous HCV Clearance-Supercontrollers. Front Immunol. 2018 Dec 10;9:2897. 

  19. Martínez-Bonet M, Muñoz-Fernández MA, Álvarez S. HIV-1 increases extracellular amyloid-beta levels through neprilysin regulation in primary cultures of human astrocytes. J Cell Physiol. 2019 May ;234(5):5880-5998.

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Laboratorio de Radicales Orgánicos. NANOMOL.ICMAB.CSIC

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  1. V. Lloveras, F. Liko, L. F. Pinto, J.L. Muñoz-Gómez, J. Veciana, J. Vidal-Gancedo. Tuning Spin-Spin Interactions in Radical Dendrimers. ChemPhysChem. 2018, 19, 1895-1902V.

  2. Lloveras, F. Liko, J. Veciana, J. L. Muñoz-Gómez, J. Vidal-Gancedo. “Redox active PTM radical dendrimers as promising multifunctional molecular switches.” Chem. Mater. 2019, 31, 9400-9412. DOI: 10.1021/acs.chemmater.9b0301

  3. L. Pinto, V. Lloveras, F. Liko, S. Zhang, J. Veciana, J.L. Muñoz-Gómez, J. Vidal-Gancedo.“Fully water-soluble polyphosphothydrazone-based radical dendrimers functionalized wit Tyr-PROXYL radical as metal-free MRI T1 contrast agents”. ACS Appl. Bio Mater. 2020, 3, 369−376. DOI: 10.1021/acsabm.9b0085

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Results 2020-2021

Results 2018-2019

 

BIONANODEN

  1. Cena-Diez, R.; Martin-Moreno, A.; de la Mata, F. J.; Gomez-Ramirez, R.; Munoz, E.; Ardoys, M.; Munoz-Fernandez, M. A.  G1-S4 or G2-S16 carbosilane dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity. Int. J. Nanomedicine 2019, 14,2371-2380.

  2. del Olmo, N. S.; Carloni, R.; Bajo, A. M.; Ortega, P.; Fattori, A.; Gomez, R.; Ottaviani, M. F.; Garcia-Gallego, S.; Cangiotti, M.; de la Mata, F. J.  Insight into the antitumor activity of carbosilane Cu(ii)-metallodendrimers through their interaction with biological membrane models. Nanoscale 2019, 11, (28),13330-13342.

  3. Fernandez, J.; Acosta, G.; Pulido, D.; Maly, M.; Copa-Patino, J. L.; Soliveri, J.; Royo, M.; Gomez, R.; Albericio, F.; Ortega, P.; de la Mata, F. J.  Carbosilane Dendron-Peptide Nanoconjugates as Antimicrobial Agents. Mol. Pharm. 2019, 16, (6),2661-2674.

  4.  Holota, M.; Magiera, J.; Michlewska, S.; Kubczak, M.; del Olmo, N. S.; Garcia-Gallego, S.; Ortega, P.; de la Mata, F. J.; Ionov, M.; Bryszewska, M.  In Vitro Anticancer Properties of Copper Metallodendrimers. Biomolecules 2019, 9, (4).

  5. Krasheninina, O. A.; Apartsin, E. K.; Fuentes, E.; Szulc, A.; Ionov, M.; Venyaminova, A. G.; Shcharbin, D.; de la Mata, F. J.; Bryszewska, M.; Gomez, R.  Complexes of Pro-Apoptotic siRNAs and Carbosilane Dendrimers: Formation and Effect on Cancer Cells. Pharmaceutics 2019, 11, (1).

  6. Maroto-Diaz, M.; del Olmo, N. S.; Munoz-Moreno, L.; Bajo, A. M.; Carmena, M. J.; Gomez, R.; Garcia-Gallego, S.; de la Mata, F. J.  In vitro and in vivo evaluation of first-generation carbosilane arene Ru(II)- metallodendrimers in advanced prostate cancer. European Polymer Journal 2019, 113,229-235.

  7. Martin-Perez, T.; Lozano-Cruz, T.; Criado-Fornelio, A.; Ortega, P.; Gomez, R.; de la Mata, F. J.; Perez-Serrano, J.  Synthesis and in vitro activity of new biguanide-containing dendrimers on pathogenic isolates of Acanthamoeba polyphaga and Acanthamoeba griffini. Parasitology Research 2019, 118, (6),1953-1961.

  8. Sanchez-Milla, M.; Munoz-Moreno, L.; Sanchez-Nieves, J.; Maly, M.; Gomez, R.; Carmena, M. J.; de la Mata, F. J.  Anticancer Activity of Dendriplexes against Advanced Prostate Cancer from Protumoral Peptides and Cationic Carbosilane Dendrimers. Biomacromolecules 2019, 20, (3),1224-1234.

  9. Vasquez-Villanueva, R.; Pena-Gonzalez, C. E.; Sanchez-Nieves, J.; de la Mata, F. J.; Marina, M. L.; Garcia, M. C.  Gold nanoparticles coated with carbosilane dendrons in protein sample preparation. Microchimica Acta 2019, 186, (8).

  10. Shcharbin, D  ; Pedziwiatr-Werbicka, E; Serchenya, T; Cyboran-Mikolajczyk, S; Prakhira, L; Abashkin, V; Dzmitruk, V; Lonov, M; Loznikova, S; Shyrochyna, L;  Sviridov, O; Pena-Gonzalez, CE ; Gumiel, AB ; Gomez, R; de la Mata, FJ; Bryszewska, M. Role of cationic carbosilane dendrons and metallic core of functionalized gold nanoparticles in their interaction with human serum albumin. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 118, 1773-1780  Subdivisión: B. DOI: 10.1016/j.ijbiomac.2018.07.023

  11. Lozano-Cruz, T ; Gomez, R; de la Mata, FJ ; Ortega, P. New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent. NEW JOURNAL OF CHEMISTRY 2018, 42 (14), 11732-11738. DOI: 10.1039/c8nj01713a

  12. Sepulveda-Crespo, D; de la Mata, FJ  ; Gómez, R  ; Muñoz-Fernandez, MA. Sutfonate-ended carbosilane dendrimers with a flexible scaffold cause inactivation of HIV-1 virions and gp120 shedding. NANOSCALE 2018, 10 (19), 8998-9011. DOI: 10.1039/c8nr01664j

  13. Guerrero-Beltran, C; Rodriguez-Izquierdo, I; Serramia, MJ; Araya-Duran, I; Marquez-Miranda, V  ; Gomez, R; de la Mata, FJ; Leal, M; Gonzalez-Nilo, F ; Muñoz-Fernandez, MA. Anionic Carbosilane Dendrimers Destabilize the GP120-CD4 Complex Blocking HIV-1 Entry and Cell to Cell Fusion. BIOCONJUGATE CHEMISTRY 2018, 29 (5), 1584-1594.DOI: 10.1021/acs.bioconjchem.8b00106.

  14. Michlewska, S; Ionov, M ; Maroto-Diaz, M; Szwed, A; Ihnatsyeu-Kachan, A; Loznikova, S; Shcharbin, D; Maly, M; Ramirez, RG; de la Mata, FJ; Bryszewska, M. Ruthenium dendrimers as carriers for anticancer siRNA. JOURNAL OF INORGANIC BIOCHEMISTRY, 2018, 181,18-27. DOI: 10.1016/j.jinorgbio.2018.01.001

  15. Heredero-Bermejo, I ; Hernandez-Ros, JM ; Sanchez-Garcia, L ; Maly, M ; Verdu-Exposito, C ; Soliveri, J ; de la Mata, FJ ; Copa-Patino, JL ; Perez-Serrano, J ; Sanchez-Nieves, J  , Gomez, R.  Ammonium and guanidine carbosilane dendrimers and dendrons as microbicides. EUROPEAN POLYMER JOURNAL, 2018,  101,  159-168. DOI: 10.1016/j.eurpolymj.2018.02.025

  16. Pedziwiatr-Werbicka, E; Serchenya, T; Shcharbin, D; Terekhova, M; Prokhira, E ; Dzmitruk, V; Shyrochyna, I; Sviridov, O; Pena-Gonzalez, CE; Gomez, R; Sanchez-Nieves, J ; de la Mata, FJ ; Bryszewska, M. Dendronization of gold nanoparticles decreases their effect on human alpha-1-microglobulin. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2018, 108, 936-941. DOI: 10.1016/j.ijbiomac.2017.11.004

  17. Sanchez-Milla, M  ; Pastor, I ; Maly, M ; Serramia, MJ ; Gomez, R  ; Sanchez-Nieves, J ; Ritort, F ; Muñoz-Fernandez, MA ; de la Mata, FJ. Study of non-covalent interactions on dendriplex formation: Influence of hydrophobic, electrostatic and hydrogen bonds interactions. COLLOIDS AND SURFACES B-BIOINTERFACES 2018, 162, 380-388. DOI: 10.1016/j.colsurfb.2017.12.009

  18. Gutierrez-Ulloa, CE ; Buyanova, MY ; Apartsin, EK ; Venyaminova, AG; de la Mata, FJ ; Gomez, R. Carbon Nanotubes Decorated with Cationic Carbosilane Dendrons and Their Hybrids with Nucleic Acids. CHEMNANOMAT 2018,4 (2), 220-230. DOI: 10.1002/cnma.201700351

 

 

Grupo Laboratorio de Glicosistemas:

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  1. Palomares, F.; Ramos-Soriano, J.; Gomez, F.; Mascaraque, A.; Bogas, G.; Richard Perkins, J.; Gonzalez, M.; Jose Torres, M.; Diaz-Perales, A.; Rojo, J.; Mayorga, C.  Pru p 3-Glycodendropeptides Based on Mannoses Promote Changes in the Immunological Properties of Dendritic and T-Cells from LTP-Allergic Patients. Molecular Nutrition & Food Research 2019, 63, (20).

  2. Ramos-Soriano, J.; Reina, J. J.; Illescas, B. M.; de la Cruz, N.; Rodriguez-Perez, L.; Lasala, F.; Rojo, J.; Delgado, R.; Martin, N.  Synthesis of Highly Efficient Multivalent Disaccharide/ 60 Fullerene Nanoballs for Emergent Viruses. Journal of the American Chemical Society 2019, 141, (38), 15403-15412.

  3. Rodriguez, M. J.; Ramos-Soriano, J.; Perkins, J. R.; Mascaraque, A.; Torres, M. J.; Gomez, F.; Diaz-Perales, A.; Rojo, J.; Mayorga, C.  Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model. Scientific Reports 2019, 9.

  4. Benede, S.; Ramos-Soriano, J.; Palomares, F.; Losada, J.; Mascaraque, A.; Carlos Lopez-Rodriguez, J.; Rojo, J.; Mayorga, C.; Villalba, M.; Batanero, E.  Peptide Glycodendrirners as Potential Vaccines for Olive Pollen Allergy. Molecular Pharmaceutics 2019, 17, (3), 827-836.

  5. Javier Ramos-Soriano, Jose Juan Reina, Beatriz M Illescas, Javier Rojo, and Nazario Martín. Maleimide and Cyclooctyne Based Hexakis-Adducts of Fullerene: Multivalent Scaffolds for Copper-Free Click Chemistry on Fullerenes. J. Org. Chem., 2018, 83, 1727−1736. DOI: 10.1021/acs.joc.7b02402

  6. Cíntia de Almeida Gonçalves, Rute Cunha Figueiredo, Alessandra Giani, Daniel Collado, Ezequiel Pérez-Inestrosa, Javier Rojo, Cleber Cunha Figueredo. Detection of glycidic receptors in microalgae using glycodendrons as probes: a new tool for studies on cell surface interactions. J. Appl. Phycol. 2018, DOI: 10.1007/s10811-018-1555-6

  7. Laura Rodríguez-Pérez, Javier Ramos-Soriano, Alfonso Pérez-Sánchez, Beatriz M. Illescas, Antonio Muñoz, Joanna Luczkowiak, Fátima Lasala, Javier Rojo, Rafael Delgado, and Nazario Martín. Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection. J. Am. Chem. Soc., 2018, 140, 9891-9898, DOI: 10.1021/jacs.8b03847

  8. Maria Jose Rodriguez, Francisca Palomares, Gador Bogas, Maria Jose Torres, Araceli Diaz-Perales, Javier Rojo, Maria del Carmen Plaza-Seron, Alba Rodriguez-Nogales, Christine Orengo, Cristobalina Mayorga,* and James Richard Perkins.Transcriptional Profiling of Dendritic Cells in a Mouse Model of Food-Antigen-Induced Anaphylaxis Reveals the Upregulation of Multiple Immune-Related PathwaysREF. REVISTA/LIBRO: Mol. Nut. Food Res. 2019, 63, DOI: 10.1002/mnfr.201800759

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Laboratorio de Dendrímeros Biomiméticos y Fotónica (LDBF)

 

  1. Noemi Molina, Francisco Nájera, Juan A. Guadix, Jose M. Perez-Pomares, Yolanda Vida and Ezequiel Perez-Inestrosa. Synthesis of Amino Terminal Clicked dendrimers. Approaches to the application as a biomarker Journal of Organic Chemistry, 2019, 84 (16), 10197-10208. DOI: 10.1021/acs.joc.9b01369

  2. Noemi Molina; Marvin Cnudde; Juan A. Guadix; Jose M. Perez-Pomares; Cristian Strassert; Yolanda Vida; Ezequiel Perez-Inestrosa. A platinum-doped dendritic structure as a phosphorescent label for bacteria in two-photon excitation microscopy.  ACS Omega, 2019, 4 (8), 13027-13033.

  3. DOI: 10.1021/acsomega.9b0063

  4. Carlos Benitez-Martin, Juan A. Guadix, John R. Pearson, Francisco Najera, Jose M. Perez-Pomares, Ezequiel Perez-Inestrosa.  A Turn-On Two-Photon Fluorescent Probe for Detecting Lysosomal Hydroxyl Radicals in Living Cells . Sensors & Actuators: B. Chemical, 2019, 284, 744-750. .DOI: 10.1016/j.snb.2018.12.163.

  5. Cíntia de Almeida Gonçalves, Rute Cunha Figueiredo, Alessandra Giani, Daniel Collado, Ezequiel Pérez-Inestrosa, Javier Rojo, Cleber Cunha Figueredo. Detection of glycidic receptors in microalgae using glycodendrons as probes: a new tool for studies on cell surface interactions . Journal of Applied Phycology, 2018, accepted. DOI: 10.1007/s10811-018-1555-6

  6. Noemi Molina, Angela Martin-Serrano, Tahia D. Fernandez, Amene Tesfaye, Francisco Najera, Maria J. Torres, Cristobalina Mayorga, Yolanda Vida, Maria I. Montañez, Ezequiel Perez-Inestrosa. Dendrimeric Antigens for Drug Allergy Diagnosis: A New Approach for Basophil Activation Tests  Molecules, 2018, 23 (5), 997.  DOI: 10.3390/molecules23050997

  7. Ignasi Casanellas, Anna Lagunas, Iro Tsintzou, Yolanda Vida, Daniel Collado, Ezequiel Pérez-Inestrosa, Cristina Rodríguez-Pereira, Joana Magalhaes, Pau Gorostiza, José A. Andrades, José Becerra, Josep Samitier. Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation  Journal of Visualized Experiments, 2018, 131, e56347.  DOI: 10.3791/56347

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Grupo de Química Orgánica Farmacéutica (POC)

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  1. Achelle, S.; Rodríguez-López, J.; Robin-le Guen, F. Photoluminescence Properties of Aryl-, Arylvinyl-, and Arylethynylpyrimidine Derivatives. ChemistrySelect 2018, 3, 1852- 1886.

  2. Castro-Osma, J. A.; Martínez, J.; de la Cruz-Martínez, F.; Caballero, M. P.; Fernández-Baeza, J.; Rodríguez-López, J; Otero, A.; Lara-Sánchez, A.; Tejeda, J.Development of hydroxy-containing imidazole organocatalysts for CO2 fixation into cyclic carbonates. Catal. Sci. Technol. 2018, 8,  1981-1987.              

  3. Tolosa, J.; Serrano de las Heras, G.; Carrión, B.; Segura, T.; Páez, P. L.; de Lera-Garrido, F. J.; Rodríguez-López, J.; García-Martínez, J. C. Structure-Activity Relationships for Poly(phenylene)vinylene Derivatives as Antibacterial Agents. ChemistrySelect, 2018,3, 7327-7332.               

  4. Domínguez, R.; Tolosa, J.; Moral, M.; Bravo, I.; Canales-Vázquez, J.; Rodríguez-López, J.; Garzón, A.; García-Martínez, J. C. pH-Controlled Self-Assembly of X-Shaped Conjugated Molecules: The Case of 1,2,4,5-Tetrastyrylbenzene. J. Phys. Chem. C 2018, 122, 19937-19945. 

  5. Mónica Moral, Rocío Domínguez, M. Paz Fernández-Liencres, Andrés Garzón-Ruiz , Joaquín C. García-Martínez, Amparo Navarro.“Photophysical features and semiconducting properties of propellershaped oligo(styryl)benzenes”  J. Chem. Phys. 2019,150, 064309.

  6. Rocío Domínguez, Juan Tolosa, Mónica Moral, Ivan Bravo, Jesus Canales-Vazquez, Julian Rodríguez-Lopez, Andres Garzon-Ruiz, Joaquín C. García-Martínez. “pH-Controlled Self-Assembly of X‑Shaped Conjugated Molecules: The Case of 1,2,4,5-Tetrastyrylbenzene” J. Phys. Chem. C 2018, 122, 19937–19945.

 

Grupo de Eduardo Fernandez-Megia

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  1. Neira, J. L.; Correa, J.; Rizzuti, B.; Santofimia-Castaño, P.; Abian, O.; Velázquez-Campoy, A.; Fernandez-Megia, E.; Iovanna, J. L. Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1.Biomacromolecules 2019, 20, 2567.

  2. Lopez-Blanco, R.; Fernandez-Villamarin, M.; Jatunov, S.; Novoa-Carballal, R.; Fernandez-Megia, E. Polysaccharides meet dendrimers to fine-tune the stability and release properties of polyion complex micelles. Polym. Chem. 2019, 10, 4709-4717.

  3. Cruz, L.; Basílio, N.; Mendoza, J.; Mateus, N.; de Freitas, V.; Tawara, M. H.; Correa, J.; Fernandez-Megia, Impact of a Water-Soluble Gallic Acid-Based Dendrimer on the Color-Stabilizing Mechanisms of Anthocyanins. E. Chem. Eur. J. 2019, 25, 11696.

  4. Vukojicic, P.; Béhar, G.; Tawara, M. H.; Fernandez-Villamarin, M.; Pecorari, F.; Fernandez-Megia, E.; Mouratou, B. Multivalent Affidendrons with High Affinity and Specificity toward Staphylococcus aureus as Versatile Tools for Modulating Multicellular Behaviors. ACS Applied Materials & Interfaces 2019, 11, 21391.

  5. Correa, J.; Pinto, L. F.; Zhao, L.; Riguera, R.; Fernandez-Megia, E. Filtering the NMR Spectra of Complex Mixtures through Polymer-Mediated Paramagnetic Spin Relaxation. Chem. Eur. J. 2018, 24, 19236-19242.

  6. Pinto, L. F.; Correa, J.; Zhao, L.; Riguera, R.; Fernandez-Megia, E. Fast NMR Screening of Macromolecular Complexes by a Paramagnetic Spin Relaxation Filter. ACS Omega 2018, 3, 2974-2983.

  7. Amaral, S. P.; Tawara, M. H.; Fernandez-Villamarin, M.; Borrajo, E.; Martínez-Costas, J.; Vidal, A.; Riguera, R.; Fernandez-Megia, E. Tuning the Size of Nanoassembles: A Hierarchical Transfer of Information from Dendrimers to Polyion Complexes. Angew. Chem., Int. Ed. 2018, 57, 5273-5277.

  8. Yemisci, M.; Caban, S.; Fernandez-Megia, E.; Capan, Y.; Couvreur, P.; Dalkara, T. Preparation and Characterization of Biocompatible Chitosan Nanoparticles for Targeted Brain Delivery of Peptides. In Neurotrophic Factors: Methods and Protocols; Skaper, Ed.; Springer New York: New York, NY, 2018, p 443-454.P

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Grupo Laboratorio Inmuno-Biología Molecular. Aplicaciones Biomédicas de Nanopartículas.

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  1. Benito JM, Ortiz MC, León A, Sarabia LA, Ligos JM, Montoya M, Garcia M, Ruiz-Mateos E, Palacios R, Cabello A, Restrepo C, Rodriguez C, Del Romero J, Leal M, Muñoz-Fernández MA, Alcamí J, García F, Górgolas M, Rallón N; ECRIS integrated in the Spanish AIDS Research Network. Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers. BMC Med. 2018 Feb 28;16(1):30. 

  2. Sánchez-Milla M, Pastor I, Maly M, Serramía MJ, Gómez R, Sánchez-Nieves J, Ritort F, Muñoz-Fernández MÁ, de la Mata FJ. Study of non-covalent interactions on dendriplex formation: influence of hydrophobic, electrostatic and hydrogen bonds interactions. Colloids Surf B Biointerfaces. 2018 Feb 1;162:380-388. 

  3. Ezequiel Ruiz-Mateos, Laura Tarancon-Diez, Ana I. Alvarez-Ríos, Beatriz Dominguez-Molina Migue Genebat, Ildefonso Pulido, Maria Antonia Abad, Mª Angeles Muñoz-Fernández, Manuel Leal. Association of heterozygous CCR5Δ32 deletion with survival in HIV-infection: A cohort study. Antiviral Res. 2018 Feb;150:15-19. 

  4. Guardo AC, Gómez CE, Díaz-Brito V, Pich J, Arnaiz JA, Perdiguero B, García-Arriaza J, González N, Sorzano COS, Jiménez L, Jiménez JL, Muñoz-Fernández MÁ, Gatell JM, Alcamí J, Esteban M, de Quirós JCLB, García F, Plana M; RISVAC02boost study. Correction: Safety and vaccine-induced HIV-1 immune responses in healthy volunteers following a late MVA-B boost 4 years after the last immunization. PLoS One. 2018 Apr 10;13(4):e0195915. 

  5. María Isabel Gonzalez-Tomé, Cristina García-Navarro, Beatriz Ruiz-Saez, Talía Sainz, Santiago Jiménez de Ory, Pablo Rojo, María José Mellado Peña, Luiz Prieto, Mª Angeles Muñoz-Fernández, Bearta, Zamora et al. Sleep Profile and Self-Reported Neuropsychiatric Symptoms in Vertically HIV-Infected Adolescents on cART.  J Pediatr Infect Dis. 2018; Abril 13(04): 300-307.

  6. Salinas-Muñoz L, Campos-Fernández R, Mercader E, Olivera-Valle I, Fernández-Pacheco C, Matilla L, García-Bordas J, Brazil JC, Parkos CA, Asensio F, Muñoz-Fernández MA, Hidalgo A, Sánchez-Mateos P, Samaniego R, Relloso M. Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to Candida albicans. Front Immunol. 2018 May 24;9:1033.  

  7. Sepúlveda-Crespo D, de la Mata FJ, Gómez R, Muñoz-Fernández MA. Sulfonate-ended carbosilane dendrimers with a flexible scaffold cause inactivation of HIV-1 virions and gp120 shedding. Nanoscale. 2018 May 17;10(19):8998-9011. .

  8. Bártolo I, Diniz AR, Borrego P, Ferreira JP, Bronze MR, Barroso H, Pinto R, Cardoso C, Pinto JF, Diaz RC, Broncano PG, Muñoz-Fernández MA, Taveira N. Correction: Evaluation of the fusion inhibitor P3 peptide as a potential microbicide to prevent HIV transmission in women. PLoS One. 2018 May 2;13(5):e0197015. eCollection 2018. Erratum in: PLoS One. 2018 Apr 18;13(4):e0195744. 

  9. Tarancon-Diez L, De Pablo-Bernal RS, Jiménez JL, Álvarez-Ríos AI, Genebat M, Rosado-Sánchez I, Muñoz-Fernández MÁ, Ruiz-Mateos E, Leal M. Role of toll-like receptor 4 Asp299Gly polymorphism in the development of cardiovascular diseases in HIV-infected patients. AIDS. 2018 May 15;32(8):1035-1041. 

  10. Guerrero-Beltran C, Rodriguez-Izquierdo I, Serramia MJ, Araya-Durán I, Márquez-Miranda V, Gomez R, de la Mata FJ, Leal M, González-Nilo F, Muñoz-Fernández MA. Anionic Carbosilane Dendrimers Destabilize the GP120-CD4 Complex Blocking HIV-1 Entry and Cell to Cell Fusion. Bioconjug Chem. 2018 May 16;29(5):1584-1594. I

  11. Gutiérrez-Rivas M, Jiménez-Sousa MÁ, Rallón N, Jiménez JL, Restrepo C, León A, Montero-Alonso M, González-García J, Muñoz-Fernández MÁ, Benito JM, Resino S; ECRIS Integrated in the Spanish AIDS Research Network. High Plasma Levels of sTNF-R1 and CCL11 Are Related to CD4+ T-Cells Fall in Human Immunodeficiency Virus Elite Controllers With a Sustained Virologic Control. Front Immunol. 2018 Jun 18;9:1399.

  12. Medrano LM, Garcia-Broncano P, Berenguer J, González-García J, Jiménez-Sousa MÁ, Guardiola JM, Crespo M, Quereda C, Sanz J, Canorea I, Carrero A, Hontañón V, Muñoz-Fernández MÁ, Resino S; GESIDA 3603b Study Group. Elevated liver stiffness is linked to increased biomarkers of inflammation and immune activation in HIV/hepatitis C virus-coinfected patients. AIDS. 2018 Jun 1;32(9):1095-1105. 

  13. Rosado-Sánchez I, Herrero-Fernández I, Genebat M, Del Romero J, Riera M, Podzamczer D, Olalla J, Vidal F, Muñoz-Fernández MA, Leal M, Pacheco YM. HIV-Infected Subjects With Poor CD4 T-Cell Recovery Despite Effective Therapy Express High Levels of OX40 and α4β7 on CD4 T-Cells Prior Therapy Initiation. Front Immunol. 2018 Jul 18;9:1673. e

  14. Puertas MC, Gómez-Mora E, Santos JR, Moltó J, Urrea V, Morón-López S, Hernández-Rodríguez A, Marfil S, Martínez-Bonet M, Matas L, Muñoz-Fernández MA, Clotet B, Blanco J, Martinez-Picado J. Impact of intensification with raltegravir on HIV-1-infected individuals receiving monotherapy with boosted PIs. J Antimicrob Chemother. 2018 Jul; 73(7): 1940–1948. 

  15. Correa-Rocha R, Lopez-Abente J, Gutierrez C, Pérez-Fernández VA, Prieto-Sánchez A, Moreno-Guillen S, Muñoz-Fernández MÁ, Pion M. CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion. PLoS One. 2018 Aug 30;13(8):e0203419. 

  16. Lopez-Abente J, Prieto-Sanchez A, Muñoz-Fernandez MÁ, Correa-Rocha R, Pion M. Human immunodeficiciency virus type-1 induces a regultaory B cell-like phenotype in vitro. Cell Mol Immunol. 2018 Oct;15(10):917-933.

  17. Tagarro A, Chan M, Zangari P, Ferns B, Foster C, De Rossi A, Nastouli E, Muñoz-Fernández MA, Gibb D, Rossi P, Giaquinto C, Babiker A, Fortuny C, Freguja R, Cotugno N, Judd A, Noguera-Julian A, Navarro ML, Mellado MJ, Klein N, Palma P, Rojo P. Early and Highly Suppressive Antiretroviral Therapy Are Main Factors Associated With Low Viral Reservoir in European Perinatally HIV-Infected Children. J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):269-276. 

  18. Dominguez-Molina B, Ferrando-Martinez S, Tarancon-Diez L, Hernandez-Quero J, Genebat M, Vidal F, Muñoz-Fernandez MA, Leal M, Koup R, Ruiz-Mateos E. Immune Correlates of Natural HIV Elite Control and Simultaneous HCV Clearance-Supercontrollers. Front Immunol. 2018 Dec 10;9:2897. 

  19. Martínez-Bonet M, Muñoz-Fernández MA, Álvarez S. HIV-1 increases extracellular amyloid-beta levels through neprilysin regulation in primary cultures of human astrocytes. J Cell Physiol. 2019 May ;234(5):5880-5998.

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Laboratorio de Radicales Orgánicos. NANOMOL.ICMAB.CSIC

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  1. V. Lloveras, F. Liko, L. F. Pinto, J.L. Muñoz-Gómez, J. Veciana, J. Vidal-Gancedo. Tuning Spin-Spin Interactions in Radical Dendrimers. ChemPhysChem. 2018, 19, 1895-1902V.

  2. Lloveras, F. Liko, J. Veciana, J. L. Muñoz-Gómez, J. Vidal-Gancedo. “Redox active PTM radical dendrimers as promising multifunctional molecular switches.” Chem. Mater. 2019, 31, 9400-9412. DOI: 10.1021/acs.chemmater.9b0301

  3. L. Pinto, V. Lloveras, F. Liko, S. Zhang, J. Veciana, J.L. Muñoz-Gómez, J. Vidal-Gancedo.“Fully water-soluble polyphosphothydrazone-based radical dendrimers functionalized wit Tyr-PROXYL radical as metal-free MRI T1 contrast agents”. ACS Appl. Bio Mater. 2020, 3, 369−376. DOI: 10.1021/acsabm.9b0085

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