Grupo de Química Orgánica Farmacéutica

(POC)

Research lines

The Pharmaceutical Organic Chemistry research group (POC) is an emerging group set up when School of Pharmacy of Albacete was founded in 2010. Our research interest focus on four main objectives:

1.- Design of new light emitters controlling their molecular structure, their supramolecularity, and other technological aspects such as the deposition method.

2.- Search for molecules that self-assemble forming micelles that encapsulate structures of interest (drugs, etc.) and that disaggregate releasing them in response to different pathological stimuli (aberrant concentrations of protein, pH, etc.)

3.- Synthesis of organogels in biocompatible lipophilic media as drug delivery carriers.

4.- Study of fluorescent sensors that respond to changes in concentration of various analytes in the medium, either modifying the energy of their orbital frontiers or their form of aggregation.

Researchers

Joaquín C. García-Martínez
Julián Rodríguez López
Juan Tolosa Barrilero
Antonio Sánchez Ruiz
Rocío Domínguez Martín
Almudena Ruiz García
Fernando J. de Lera Garrido
Víctor Vázquez Villar
Sergio González Alfaro

Fundings (last 5 years selection)

1.- Ministerio de Economía, Industria y Competitividad. Supramolecularidad en polifenilenvinilenos luminiscentes: Control y optimización de la agregación para impresión 3D. Ref. CTQ2017-84561-P (2018-2021) 

2.- Junta de Comunidades de Castilla-La Mancha. Diseño de nuevos sensores de anión fluoruro y/o pH basados en sistemas pi-conjugados que incorporan anillos de diazina. Ref. SBPLY/17/180501/000214 (2018-2021)

3.- European Union. Localization of Ion Channels and Receptors by Two- and Three- Dimensional Inmunoelectron Microscopic Approaches (2014-2016)

Publications (last selection 5 years)

1.- Juan Tolosa, Gemma Serrano de las Heras, Blanca Carrión, Tomás Segura, Paulina L. Páez, Fernando J. de Lera-Garrido, Julián Rodríguez-López, and Joaquín C. García-Martínez. Structure-Activity Relationships for Poly(phenylene)vinylene Derivatives as Antibacterial Agents. Chemistry Select, 2018, 3, 7327 – 7332.

2.- Andrés Garzón, M. Paz Fernández-Liencres, Mónica Moral, Tomás Peña-Ruiz, Amparo Navarro, Juan Tolosa, Jesús Canales-Vazquez, Daniel Hermida-Merino, Iván Bravo, José Albaladejo, and  Joaquín C. García-Martínez.  Effect of the Aggregation on the Photophysical Properties of a Blue-Emitting Star-Shaped Molecule Based on 1,3,5-Tristyrylbenzene. J. Phys. Chem. C, 2017, 121 (8), 4720–4733.

3.- Manuela Martín-Zarco, Giorgi Titvinidze, Joaquín C. García-Martínez, and Julián Rodríguez-López. Sulfonated dendrimer- and hyperbranched polyglycerol-PBIOO® blend membranes for fuel cells. J. Poly. Sci. Part A. Poly. Chem. 2016, 54, 69-81.

4.- Stephen M. Bromfield, Paola Posocco, Maurizio Fermeglia, Juan Tolosa, Ana Herreros-López, Sabrina Pricl, Julián Rodríguez-López, and David K. Smith. Shape-Persistent and Adaptive Multivalency: Rigid Transgeden (TGD) and Flexible PAMAM Dendrimers for Heparin Binding. Chem. Eur. J. 2014, 20, 9666-9674.

5.- Javier Guerra, Ana Rodrigo, Sonia Merino, Juan Tejeda, Joaquín García-Martinez, Prado Sánchez-Verdú, Valentín Ceña, and Julián Rodríguez-López. PPV-PAMAM Hybrid Dendrimers: Self-Assembly and Stabilization of Gold Nanoparticles. Macromolecules. 2013, 46, 7316 – 7324.

International Collaborations

1.- Prof. Paulina L. Páez, Universidad Nacional de Córdoba  (Argentina)

2.- Prof. Sylvain Achelle, Université de Rennes 1 (Francia)

3.- Prof. David K. Smith, University of Oxford (Reino Unido)

4.- Prof. Richard M. Crooks, University of Texas at Austin (Estados Unidos)

5.- Prof. Joohoon Kim, Kyung Hee University (República de Corea)

  

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